Aim: Determination of the incidence of gastric ulcers in pigs slaughtered at Base Abattoir in Rwanda.

Materials and Methods: Stomachs from all 5040 pigs that were slaughtered at Base Abattoir in Rwanda from August 2012 to August 2015 were examined for the presence and location of gastric ulcers. The results of the inspections were recorded and analyzed. Statistical analysis for Chi-square values was performed using the Software Package for Social Sciences version 16.0. The Z test for comparison of proportions was used and p<0.05 was considered significant.

Results: Overall as well as per district, significantly more male pigs than female pigs were slaughtered (p<0.05). The incidence of gastric ulcers in slaughter pigs was 12.86%. The incidence of gastric ulcers in males (13.36%) was not significantly different (p>0.05) from that in female pigs (12.84%) in all three districts. A significantly greater proportion of these ulcers (69.03%) was located in the esophageal region than in the glandular region of the stomach (30.97%) in slaughtered males (p<0.05). A significantly greater proportion of these ulcers (79.59%) was located in the esophageal region than in the glandular region of the stomach (20.41%) in slaughtered females (p<0.05). The overall incidence of esophageal ulcers (9.44%) in the slaughtered pigs was significantly (p<0.05) higher than that of glandular region ulcers (3.41%). Pigs with carcass weight over 60 kg showed a significantly (p<0.05) higher (44.44%) incidence of ulcers than those between 40 and 60 kg (33.33%) and those below 40 kg (22.22%).

Conclusion: It was concluded that the incidence of gastric ulceration in slaughter pigs at Base Abattoir was not associated with source (district) or sex of pigs but was associated with the carcass weight.

Keywords: Base Abattoir, gastric ulcers, pigs, Rwanda.

1. Gelberg, H.B. (2012) Alimentary system and the peritoneum, omentum, mesentery, and peritoneal cavity. In: Pathologic Basis of Veterinary Disease. Mosby, St. Louis. p326-327.

2. Majekodunmi, M., Omotosho, O., Emikpe, B., Olufemi, B. and Olufemi, B. (2013) The incidence of gastric lesions in slaughtered pigs in Ibadan, Nigeria. Sokoto J. Vet. Sci., 11: 22-77. [Crossref]

3. Mishra, S.K., Mishra, V., Pandey, A.K. and Srivastava, A. (2014) Docking study of the rohitukine for the prevention of peptic ulcer - A new target. J. Phytopharm., 3: 9-15.

4. Friendship, R.M. (2004) Gastric ulceration in swine. J. Swine Health Prod., 12: 34-35.

5. Friendship, R.M. (2006) Gastric ulcers. In: Diseases of Swine. 9th ed. Blackwell Publishing, Ames, Iowa. p891-899.

6. Omotosho, O.O., Emikpe, B.O., Lasisi, O.T. and Jarikre, T.A. (2016) Prevalence, distribution and pattern of gastric lesions in slaughtered pigs in South-Western Nigeria. Onderstepoort J. Vet. Res., 83: 6. [Crossref] [PubMed]

7. Monteiro, S.D.A. (2011) Prevalence and Risk Factors for Gastrics Ulcers in Swine. Faculdade de Medicina da Universidade do Porto FMUP, Sao Paulo, Brazil.

8. Kernkamp, H.C. (1945) Gastric ulcer in swine. Am. J. Pathol., 21: 111-113. [PubMed] [PMC]

9. Melnichouk, S.I. (2002) Mortality associated with gastric ulceration in swine. Can. Vet. J., 43: 223-225. [PubMed] [PMC]

10. Canibe, N., Blaabjerg, K. and Lauridsen, C. (2016) Gastric Ulcers in Pigs. Available from: http://www.pure.au.dk/portal/files/108305983/Vidensyntese_Gastric_ulcers_in_pigs_231216.pdf.

11. Mobeler, A., Kottendorf, S., Liesner, V.G. and Kamphues, J. (2010) Impact of diets' physical form (particle size; meal/pelleted) on the stomach content (dry matter content, pH, chloride concentration) of pigs. Livest. Sci., 134: 146-148. [Crossref]

12. Zalecki, M. (2015) The influence of antral ulcers on intramural gastric nerve projections supplying the pyloric sphincter in the pig (Sus scrofa domestica) - Neuronal tracing studies. PLoS One, 10: 1-11. [Crossref] [PubMed] [PMC]

13. Friendship, R. (1999) Gastric ulcers. In: Diseases of Swine. Iowa State University, Ames, IA, USA. p685-694.

14. Appino, S., Guarda, F., Pregel, P., Amedeo, S., Cutufia, M. and Bellonio, G. (2006) Detection of helicobacter candidatus suis by PCR in oesophagogastric ulcers of swine in Italy. Acta Vet. Hung., 54: 517-524. [Crossref] [PubMed]

15. Prabhu, V. and Shivani, A. (2014) An overview of history, pathogenesis and treatment of perforated peptic ulcer disease with evaluation of prognostic scoring in adults. Ann. Med. Health Sci. Res., 4: 22-29. [Crossref] [PubMed] [PMC]

16. Paulk, C.B., Hancock, J.D., Fahrenholz, A.C., Wilson, J.M., McKinney, L.J. and Benhke, K.C. (2015) Effects of feeding cracked corn to nursery and finishing pigs. J. Anim. Sci., 93: 1710-1720. [Crossref] [PubMed]

17. Rojas, O.J., Liu, Y. and Stein, H.H. (2016) Effects of particle size of yellow dent corn on physical characteristics of diets and growth performance and carcass characteristics of growing-finishing pigs. J. Anim. Sci., 94: 619-628. [Crossref]

18. Flatlandsmo, K. and Slagsvold, P. (1971) Effect of grain particle size and pellets on development of gastric ulcers in swine. J. Anim. Sci., 33: 1263. [Crossref] [PubMed]

19. Makinde, M. and Gous, T. (1998) Prevalence of gastro-oesophageal ulcers in grower-finisher pigs in the Northern Province of South Africa: Research communication. J. S. Afr. Vet., 69: 59-60. [Crossref]

20. Swaby, H. and Gregory, N.G. (2012) A note on the frequency of gastric ulcers detected during post-mortem examination at a pig abattoir. Meat Sci., 90: 269-271. [Crossref] [PubMed]

21. Pedersen, L.J., Herskin, M.S., Forkman, B., Elvang, H. and Margit, J. (2015) Increasing amounts of straw increase growing pigs production and health. In: International Conference on Pig Welfare: Improving Pig Welfare - What are the Ways forward?. p98.

22. Millet, S., Kumar, S., De Boever, J., Ducatelle, R. and De Brabander, D. (2012) Effect of feed processing on growth performance and gastric mucosa integrity in pigs from weaning until slaughter. Anim. Feed Sci. Technol., 75: 175-181. [Crossref]

23. Millet, S., Kumar, S., De Boever, J., Meyns, T., Aluwe, M. and De Brabander, D. (2012) Effect of particle size distribution and dietary crude fibre content on growth performance and gastric mucosa integrity of growing-finishing pigs. Vet. J., 192: 316-321. [Crossref]

24. Steenkamp, J.A. (2014) The Evaluation of the Effect of Acid Buf on Stomach Ulcer Occurrence, Growth Performance and Histological Parameters of Grower - Finisher Pigs. Thesis, Stellenbosch University.

25. Liermann, W., Berk, A., Boschen, V. and Danicke, S. (2015) Effects of particle size and hydro-thermal treatment of feed on performance and stomach health in fattening pigs. Arch. Anim. Nutr., 69: 455-472. [Crossref] [PubMed]

26. Nguyen, D.H., Park, J.W. and Kim, I.H. (2016) Effect of crumbled diet on growth performance, market day age and meat quality of growing-finishing pigs. J. Appl. Anim. Res., 45: 396-399. [Crossref]

27. Di Martino, G., Capello, K, Scollo, A., Gottardo, F., Stefani, A.L. and Rampin, F. (2013) Continuous straw provision reduces prevalence of oesophago-gastric ulcer in pigs slaughtered at 170kg (heavy pigs). Res. Vet. Sci., 95: 1271-1273. [Crossref] [PubMed]

28. Herskin, M.S., Jensen, H.E., Jespersen, A., Forkman, B., Jensen, M.B. and Canibe, N. (2016) Impact of the amount of straw provided to pigs kept in intensive production conditions on the occurrence and severity of gastric ulceration at slaughter. Res. Vet. Sci., 104: 200-206. [Crossref]

29. Jensen, K.H., Jorgensen, L., Haugegaard, S., Herskin, M.S., Jensen, M.B. and Pedersen, L.J. (2017) The dose-response relationship between the amount of straw provided on the floor and gastric ulceration of pars oesophagea in growing pigs. Res. Vet. Sci., 112: 66-74. [Crossref]

30. Ayles, H.L., Friendship, R.M. and Ball, R.O. (1996) Effect of dietary particle size on gastric ulcers, assessed by endoscopic examination, and relationship between ulcer severity and growth performance of individually fed pigs. Swine Heal. Prod., 4(5): 211-216.

31. Haesebrouck, F., Pasmans, F., Flahou, B., Chiers, K., Baele, M. and Meyns, T. (2009) Gastric Helicobacters in domestic animals and nonhuman primates and their significance for human health. Clin. Microbiol. Rev., 22: 202-223. [Crossref] [PubMed] [PMC]

32. Baele, M., Decostere, A., Vandamme, P., Ceelen, L., Hellemans, A. and Mast, J. (2008) Isolation and characterization of Helicobacter suis sp. Nov. from pig stomachs. Int. J Syst. Evol. Microbiol., 58: 1350-1358. [Crossref] [PubMed]

33. Barbosa, A.J.A., Silva, J.C.P., Nogueira, A.M.M., Paulino, E. and Miranda, C.R. (1995) Higher incidence of Gastrospirillum sp. in swine with gastric ulcer of the pars oesophagea. Vet. Pathol., 32: 134-139. [Crossref] [PubMed]

34. Sumiyama, K., Gostout, C.J., Rajan, E., Bakken, T.A., Deters, J.L. and Knipschield, M.A. (2007) Endoscopic full-thickness closure of large gastric perforations by use of tissue anchors. Gastrointest. Endosc., 65: 134-139. [Crossref] [PubMed]

35. Elbers, A.R., Hessing, M.J., Tielen, M.J. and Vos, J.H. (1995) Growth and oesophagogastric lesions in finishing pigs offered pelleted feed ad libitum. Vet. Rec., 36: 588-590. [Crossref]

36. Eisemann, J.H., Morrow, W.E.M., See, M.T., Davies, P.R. and Zering, K. (2002) Effect of feed withdrawal prior to slaughter on prevalence of gastric ulcers in pigs. J. Am. Vet. Med. Assoc., 220: 503-506. [Crossref] [PubMed]

37. Robertson, I.D., Accioly, J.M., Moore, K.M., Driesen, S.J., Pethick, D.W. and Hampson, D.J. (2002) Risk factors for gastric ulcers in Australian pigs at slaughter. Prev. Vet. Med., 53: 293-303. [Crossref]

38. Grosse, L.V., Taube, V., Leonhard-Marek, S., Beineke, A. and Kamphues, J. (2009) Integrity of gastric mucosa in reared piglets - Effects of physical form of diets (meal/pellets), pre-processing grinding (coarse/fine) and addition of lignocellulose (0/2.5%). J. Anim. Physiol. Anim. Nutr., 93: 373-380. [Crossref] [PubMed]

39. Kopinski, J.S., Fogarty, R. and McVeigh, J. (2007) Effect of S-methylmethionine sulphonium chloride on oesophagogastric ulcers in pigs. Aust. Vet. J., 85: 362-367. [Crossref] [PubMed]

40. Bubenik, G.A. (2008) Thirty four years since the discovery of gastrointestinal melatonin. J. Physiol. Pharmacol., 59: 33-51. [PubMed]

41. Friendship, R.M. (2016) Gastric ulcers in pigs. In: The Merck Veterinary Manual. 11th ed. Available from: http://www.msdvetmanual.com/digestive-system/gastrointestinal-ulcers-in-large-animals/gastric-ulcers-in-pigs. Last accessed on 06-12-2016.

42. Banga-Mboko, H., Tamboura, H., Maes, D., Traore, H., Youssao, I. and Sangild, P.T. (2003) Survey of gastric lesions and blood pepsinogen levels in pigs in Burkina Faso. Vet. Res. Commun., 27: 595-602. [Crossref] [PubMed]

43. Amory, J.R., Mackenzie, A.M. and Pearce, G.P. (1974) Factors in the housing environment of finisher pigs associated with the development of gastric ulcers. Vet. Rec., 158: 260-264. [Crossref]

44. Bivin, W.S., De Barros, C.L. and De Barros, S.S. (1974) Gastric ulcers in Brazilian swine. J. Am. Vet. Med. Assoc., 164: 405-407. [PubMed]

45. Muggenburg, B.A., Mcnutt, S.H. and Kowalczyk, T. (1964) Pathology of gastric ulcers in swine. Am. J. Vet. Res., 25: 1354-1365.

46. Berruecos, J.M. and Robison, O.W. (1972) Inheritance of gastric ulcers in swine. J. Anim. Sci., 35: 20. [Crossref] [PubMed]

47. Curtin, T.M., Goetsch, G.D. and Hollandbeck, R. (1963) Clinical and pathologic characterization of esophagogastric ulcers in swine. J. Am. Vet. Med. Assoc., 143: 854-860. [PubMed]

48. Choi, Y.K., Han, J.H. and Joo, H.S. (2001) Identification of novel Helicobacter species in pig stomachs by PCR and partial sequencing. J. Clin. Microbiol., 39: 3311-3315. [Crossref] [PubMed] [PMC]

49. Queiroz, D.M., Rocha, G.A., Mendes, E.N., De Moura, S.B., De Oliveira, A.M. and Miranda, D. (1996) Association between Helicobacter and gastric ulcer disease of the pars esophagea in swine. Gastroenterology, 111: 19-27. [Crossref] [PubMed]

50. Roosendaal, R., Vos, J.H., Roumen, T., van Vugt, R., Cattoli, G. and Bart, A. (2000) Slaughter pigs are commonly infected by closely related but distinct gastric ulcerative lesion-inducing gastrospirilla. J. Clin. Microbiol., 38: 2661-2664. [PubMed] [PMC]

51. Guise, H.J., Carlyle, W.W., Penny, R.H., Abbott, T.A., Riches, H.L. and Hunter, E.J. (1997) Gastric ulcers in finishing pigs: Their prevalence and failure to influence growth rate. Vet. Rec., 141: 563-566. [Crossref]

52. Dobson, K.J., Davies, R.L. and Cargill, C.F. (1978) Ulceration of the pars oesophagia in pigs. Aust. Vet. J., 54: 601-602. [Crossref] [PubMed]

53. Lawrence, B.V., Anderson, D.B., Adeola, O. and Cline, T.R. (1998) Changes in pars esophageal tissue appearance of the porcine stomach in response to transportation, feed deprivation, and diet composition. J. Anim. Sci., 76: 788. [Crossref]

54. Mahan, D.C., Pickett, R.A., Perry, T.W., Curtin, T.M., Featherston, W.R. and Beeson, W.M. (1966) Influence of various nutritional factors and physical form of feed on esophagogastric ulcers in swine. J. Anim. Sci., 25: 1019-1023. [Crossref] [PubMed]

55. De Jong, J.A., De Rouchey, J.M., Tokach, M.D., Dritz, S.S., Goodband, R.D. and Woodworth, J.C. (2016) Evaluating pellet and meal feeding regimens on finishing pig performance, stomach morphology, and carcass characteristics. Kansas Agric. Exp. Stn. Res. Rep., 94: 4781-4788. [Crossref]

56. Overholt, M.F., Lowell, J.E., Arkfeld, E.K., Grossman, I.M., Stein, H.H. and Dilger, A.C. (2016) Effects of pelleting diets without or with distillers' dried grains with solubles on growth performance, carcass characteristics, and gastrointestinal weights of growing-finishing barrows and gilts. J. Anim. Sci., 94: 2172-2183. [Crossref]