Open Access
Research
(Published
online: 13-01-2017)
8.
Transcriptomic comparison of primary bovine
horn core carcinoma culture and parental tissue at early stage -
Sharadindu Shil,
R. S. Joshi,
C. G. Joshi, A. K. Patel, Ravi K. Shah, Namrata Patel, Subhash J.
Jakhesara, Sumana Kundu, Bhaskar Reddy, P. G. Koringa
and D. N. Rank
Veterinary World, 10(1): 38-55
doi:
10.14202/vetworld.2017.38-55
Sharadindu Shil :
Veterinary
Officer (WBAH & VS), West Bengal Animal Resources Development
Department, Bankura - 772 152 , West Bengal, India;
Department of
Animal Genetics & Breeding, College of Veterinary Sciences and
Animal Husbandry, Anand Agricultural University, Anand, Gujarat,
India.
R. S. Joshi :
Department of
Animal Genetics & Breeding, College of Veterinary Sciences and
Animal Husbandry, Anand Agricultural University, Anand, Gujarat,
India.
C. G. Joshi :
Department of
Animal Biotechnology, College of Veterinary Sciences and Animal
Husbandry, Anand Agricultural University, Anand, Gujarat, India.
A. K. Patel :
Hester Biosciences
Limited, Ahmedabad, Gujarat, India.
Ravi K. Shah :
Department of
Animal Biotechnology, College of Veterinary Sciences and Animal
Husbandry, Anand Agricultural University, Anand, Gujarat, India.
Namrata Patel :
Department of
Animal Biotechnology, College of Veterinary Sciences and Animal
Husbandry, Anand Agricultural University, Anand, Gujarat, India.
Subhash J.
Jakhesara :
Department of
Animal Biotechnology, College of Veterinary Sciences and Animal
Husbandry, Anand Agricultural University, Anand, Gujarat, India.
Sumana Kundu :
Veterinary Officer,
MVC Sarenga, Government of West Bengal, Bankura, West Bengal,
India.
Bhaskar Reddy :
Department of
Animal Biotechnology, College of Veterinary Sciences and Animal
Husbandry, Anand Agricultural University, Anand, Gujarat, India.
P. G. Koringa :
Department of
Animal Biotechnology, College of Veterinary Sciences and Animal
Husbandry, Anand Agricultural University, Anand, Gujarat, India.
D. N. Rank :
Department of
Animal Genetics & Breeding, College of Veterinary Sciences and
Animal Husbandry, Anand Agricultural University, Anand, Gujarat,
India.
Received: 19-09-2016, Accepted: 29-11-2016, Published online:
13-01-2017
Corresponding author:
D. N. Rank,
e-mail: dnrank@gmail.com
Citation:
Shil S, Joshi RS, Joshi CG, Patel AK, Shah RK, Patel N, Jakhesara
SJ, Kundu S, Reddy B, Koringa PG, Rank DN (2017) Transcriptomic
comparison of primary bovine horn core carcinoma culture and
parental tissue at early stage, Veterinary World, 10(1):
38-55.
Abstract
Aim:
Squamous cell
carcinoma or SCC of horn in bovines (bovine horn core carcinoma)
frequently observed in Bos indicus affecting almost 1% of
cattle population. Freshly isolated primary epithelial cells may
be closely related to the malignant epithelial cells of the tumor.
Comparison of gene expression in between horn’s SCC tissue and its
early passage primary culture using next generation sequencing was
the aim of this study.
Materials and
Methods:
Whole
transcriptome sequencing of horn’s SCC tissue and its early
passage cells using Ion Torrent PGM were done. Comparative
expression and analysis of different genes and pathways related to
cancer and biological processes associated with malignancy,
proliferating capacity, differentiation, apoptosis, senescence,
adhesion, cohesion, migration, invasion, angiogenesis, and
metabolic pathways were identified.
Results:
Up-regulated
genes in SCC of horn’s early passage cells were involved in
transporter activity, catalytic activity, nucleic acid binding
transcription factor activity, biogenesis, cellular processes,
biological regulation and localization and the down-regulated
genes mainly were involved in focal adhesion, extracellular matrix
receptor interaction and spliceosome activity.
Conclusion:
The
experiment revealed similar transcriptomic nature of horn’s SCC
tissue and its early passage cells.
Keywords:
cummerbund, gene ontology, primary culture, RNA-sequencing,
squamous cell carcinoma of horn, transcriptome profiling.
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