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Review
12.
Epidemiological assessment of vaccine efficacy -
G. V. Asokan
Vet World. 2009; 2(3): 118-122
Abstract
The success
of an epidemiological program against infectious diseases
depends on an effective prophylactic vaccine. Although efficacy
and effectiveness are used interchangeably, effectiveness
depends upon efficacy. Few methods are in use to assess the
efficacy of the vaccine, a randomized double blind controlled
trial is the least ambiguous method for evaluation.
Observational designs for vaccine efficacy include cohort and
case control and are useful when comparing vaccines with very
large effectiveness. Modeling helps in designing vaccine.
Serologic responses to antigens in combination vaccine differ
from those obtained with separate administration of the
components. Creation of a vaccine advisory and control authority
is imminent.
Keywords:
Vaccine efficacy, epidemiology
