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Review
13.
Antifungal drug resistance - concerns for veterinarians -
Bharat B. Bhanderi, Mahendra Mohan Yadav, Ashish Roy
Vet World. 2009; 2(5): 204-207
doi: 10.5455/vetworld.2009.204-207
Abstract
In the
1990s, there were increased incidences of fungal infectious
diseases in human population, which might be due to increase in
immunosuppressive diseases. But the major concern was increase
in prevalence of resistance to antifungal drugs, which were
reported both in the fungal isolates of human beings and that of
animal origin. In both animals and human beings, resistance to
antimicrobial agents has important implications for morbidity,
mortality and health care costs, because resistant strains are
responsible for bulk of infection in animals and human beings,
and large number of antimicrobial classes offers more diverse
range of resistance mechanisms to study and resistance
determinants move into standard well-characterized strains that
facilitates the detailed study of molecular mechanisms of
resistance in microorganisms. Studies on resistance to
antifungal agents has been lagging behind that of antibacterial
resistance for several reasons, the foremost reason might be
fungal agents were not recognized as important animal and human
pathogens, until relatively in recent past. But the initial
studies of antifungal drug resistance in the early 1980s have
accumulated a wealth of knowledge concerning the clinical,
biochemical, and genetic aspects of this phenomenon. Presently,
exploration of the molecular aspects for antifungal drug
resistance has been undertaken. Recently, the focus was on
several points like developing a more detailed understanding of
the mechanisms of antimicrobial resistance, improved methods to
detect resistance when it occurs, methods to prevent the
emergence and spread of resistance and new antimicrobial options
for the treatment of infections caused by resistant organisms.
Keywords:
Antifungal, Incidence, Infection, Disease, Immunosuppression,
Human, Population.
