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Research
4.
Safety
evaluation studies of Citrullus colocynthis for
diabetes in rats -
S.K Atole,
C.R Jangde, Preety Philip, D.S Rekhe, D.V. Aghav, H.J.
Waghode and A.M.Chougule
Veterinary
World 2(11):423-425
Abstract
An
experiment conducted in the department of
Pharmacology and Toxicology, Nagpur Veterinary
College, Nagpur reported Citrullus colocynthis to
posses antidiabetic effect in rats at the rate of 50
mg/kg b.w and 100mg/kg b.w. So it was decided to
also evaluate the safety of Citrullus colocynthis in
rats at its antidiabetic dose. The experiment was
conducted for 28 days .18 wistar rats were divided
into three groups containing six rats in each group.
Group T1 was maintained as normal control, whereas
groups T2 and T3 received aqueous extract of
Citrullus colocynthis @ 50 and 100 mg/kg body
weight. Haematological and Biochemical estimations
were done at the end of experiment i.e. on 29th day
by using standard kits. Rats were then sacrificed
and histopathological examinations were done. The
results obtained showed that Citrullus colocynthis
is safe at its antidiabetic dose and is safe for use
as an antidiabetic remedy.
Keywords: Diabetes, Safety Evaluation,
Metabolic disease, Herbal drug.
