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Research
10. Evaluation of analgesic activity of
lotus seeds (Nelumbo nucifera) in albino rats - P.
Vikrama Chakravarthi and N. Gopakumar
Veterinary World 2(9):355-357
Abstract
The present
study was undertaken to assess the analgesic effect of red and
white lotus (Nelumbo nucifera) seeds
in albino rats. The analgesic action in acute pain model was
studied by tail flick method. The methanolic extracts
of lotus seeds were screened for phytochemical analysis
and it’s revealed the presence of all components excluding
tannins. The Forty eight adult Sprague-Dawley rats
were divided into six groups of eight each and maintained under
ideal laboratory conditions. Group I was taken as control and
group II treated with the standard drug diclofenac potassium
@ 3mg/kg on 7thday
of study. The methanolic extract
of Nelumbo nucifera seeds
of red and white varieties @ 400mg/kg and 600mg/kg were fed to
group III, IV, V and VI respectively, for 7 days. It
is observed that the both lotus seed extracts shows considerable
analgesic effect in acute pain model which is less than the
effect of Diclofenac group.
The higher dose groups of lotus seed extracts (600mg/kg) were
revealed more activity than their corresponding lower dose.
While evaluating all groups, the higher dose group of white
lotus seed (600mg/kg), exhibited more pronounced activity than
other extracts.
Keywords: Analgesic
activity, Lotus seeds, Tail Flick method, Pain.
