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Research
6.
Immunomodulatory effect of Ocimum
sanctum against endosulfan induced immunotoxicity in
wistar rat -
B. K. Bharath, Y. Anjaneyulu and Ch. Srilatha
Veterinary World, 2011, 4(1) : 25-27
doi:
10.5455/vetworld.2011.25-27
Abstract
The present experiment was designed to make a
systematic study of experimentally induced
immunotoxicity of endosulfan and its amelioration
with Ocimum sanctum in male Wistar rats at 6, 3 and
1.5 mg / Kg b.wt to groups II, III and IV by mixing
in ground nut oil for 6 weeks. To the groups V, VI
and VII in addition to endosulfan as above mentioned
dose, Ocimum sanctum was given at 200 mg / kg b.wt
daily per orally for the same duration to study
immunomodulatory effect. Group I served as oil
control and Group VIII as Ocimum sanctum control.
Significant reduction in the both HA titer and DNCB
contact sensitivity score was observed in the
endosulfan treated groups indicates endosulfan has
immunotoxic effect. But significant improvement in
the immunity was observed in the Ocimum sanctum
treated groups indicates the immunomodulatory
property.
Keywords: Immunodulator, Toxicity, Herbal
Drug,
