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Research
(Published
online: 05-08-2014)
4.
Clinicophysiological, haematobiochemical and haemodynamic effect
of propofol and ketamine with dexmedetomidine in urolithic goats
- Rohit Kumar, P. Kinjavdekar, Amarpal, H. P. Aithal, A. M. Pawde,
A. Kumar, J. Singh, S. Khattri and D. N. Madhu
Veterinary World, 7(8): 566-573
doi:
10.14202/vetworld.2014.566-573
Rohit Kumar: Division of Surgery, Indian Veterinary Research
Institute, Izatnagar - 243122, Uttar Pradesh, India;
drrohits.singh@gmail.com
P. Kinjavdekar: Division of Surgery, Indian Veterinary
Research Institute, Izatnagar - 243122, Uttar Pradesh, India;
p.kinjavdekar@rediffmail.com
Amarpal: Division of Surgery, Indian Veterinary Research
Institute, Izatnagar - 243122, Uttar Pradesh, India; dramarpal@gmail.com
H. P. Aithal: Division of Surgery, Indian Veterinary Research
Institute, Izatnagar - 243122, Uttar Pradesh, India; hpaithal@rediffmail.com
A. M. Pawde: Division of Surgery, Indian Veterinary Research
Institute, Izatnagar - 243122, Uttar Pradesh, India; abhimp@rediffmail.com
A. Kumar: Division of Animal Genetics, Indian Veterinary
Research Institute, Izatnagar - 243122, Uttar Pradesh, India;
vetamitchandan07@gmail.com
J. Singh: Division of Surgery, Indian Veterinary Research
Institute, Izatnagar - 243122, Uttar Pradesh, India;
vet_jasmeetsingh@rediffmail.com
S. Khattri: Division of Surgery, Indian Veterinary Research
Institute, Izatnagar - 243122, Uttar Pradesh, India;
siddharthkhattri@gmail.com
D. N. Madhu: Division of Surgery, Indian Veterinary Research
Institute, Izatnagar - 243122, Uttar Pradesh, India;
madhu63vsr@gmail.com
Received: 09-04-2014, Revised: 17-06-2014, Accepted: 24-06-2014,
Published online: 05-08-2014
Corresponding author: Rohit Kumar, email:
drrohits.singh@gmail.com
Abstract
Aim: To compare
clinicophysiological, haematobiochemical and haemodynamic effects
of propofol and ketamine total intravenous anaesthesia (TIVA) with
dexmedetomidine in uraemic goats.
Materials and Methods: Prospective, randomized clinical
trials were performed in sixteen clinical cases of urolithiasis in
goats. After sedation with dexmedetomidine (2.5 µg/kg body wt)
anaesthesia was induced and maintained with propofol in group
Dexmedetomidine+Propofol (DP) and with ketamine in group
Dexmedetomidine+Ketamine (DK). Continuous intravenous infusion (CII)
was used with respective drug for maintenance of anaesthesia.
Infusion rate was adjusted in response to positive reactions to
surgical nociceptive stimulation performed during tube cystostomy
procedure or by observing pedal reflex after completion of surgery
till discontinuation of anaesthesia. Clinicophysiological,
haematobiochemical and haemodynamic parameters were measured
before treatment (baseline), after sedation and during anaesthesia.
Two-way analysis of variance with repeated measurements was used
to analyze the data.
Results: Mean values of equipotent induction and
maintenance dose in group DP were (2.50±0.37 mg/kg and 0.15±0.03
mg/kg/min) significantly lower (9.85±0.85 mg/kg and 0.54±0.07
mg/kg/min) than DK. Heart rate decreased significantly (p<0.05) up
to the end of observation period after induction of anaesthesia
with propofol. However, after induction of anaesthesia with
ketamine HR improved at 15 min and onwards. Mean arterial pressure
(MAP) decreased significantly (p<0.05) at 15 min onwards up to the
end of observation period in DP group. However, in DK group, MAP
decreased non-significantly (p>0.05) up to the end of the
observation period after induction of anaesthesia with ketamine.
Conclusion: Both drug combinations are suitable for
induction and maintenance anaesthesia for one hour, with good
analgesia and haemodynamic stability. However, treatment DP
produced excellent sedation and muscle relaxation.
Keywords: dexmedetomidine, goats, ketamine, propofol.
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