Open Access
Copyright: The authors. This article is an open access
article licensed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/2.0) which permits unrestricted use,
distribution and reproduction in any medium, provided the work is properly
cited.
Research
(Published
online: 13-06-2014)
8. Association of periodontitis and
chronic kidney disease in dogs - S. U. Nabi, A. R Wani,
O. S. Shah and S. Dey
Veterinary World, 7(6): 403-407
doi:
10.14202/vetworld.2014.403-407
S. U. Nabi: Division of Veterinary Medicine, Indian
Veterinary Research Institute, Izatnagar - 243122, Uttar Pradesh,
India.
A. R. Wani: Department of Veterinary Pharmacology And
Toxicology, College of Veterinary Science, Assam Agricultural
University, Khanapara, Guwahati- 781022, Assam, India;
O. S. Shah: Department of Veterinary Medicine, SKUAST-K,
Srinagar- 192301, Jammu and Kashmir, India.
S. Dey: Division of Veterinary Medicine, Indian Veterinary
Research Institute, Izatnagar - 243122, Uttar Pradesh, India.
Received: 14-01-2014, Revised: 10-02-2014, Accepted: 12-02-2014,
Re-revised: 07-06-2014, Published online: 13-06-2014
Corresponding author: Abdul Rakeeb Wani, email:
etheralecho@gmail.com, Cell: +91-9906958601.
Abstract
Aim: The purpose of our study
is to study the etiopathogenesis of periodontitis in chronic
kidney disease and to identify a correlation between periodontitis
and chronic kidney disease, with the help of periodontal
exaamination, ultrasonographic and hematobiochemical analysis.
Materials and Methods: 46 dogs with renal failure were
studied and classified as presenting a slight (56.52%), moderate
(36.95%) and severe (47.8%) degree of periodontal disease.
Results: Marked gingival recession involving whole
maxillary dental arcade, Oral mucosa ulcers and tissue necrosis
and mobility of mandibular incisors was observed in dogs with
chronic kidney disease. Dogs with normal renal function were
observed to have minimal gingival recession of the mandibular
teeth only.
Conclusion: In view of the causative association between
periodontal infection, generalized inflammation and important
systemic diseases like chronic kidney disease, we hypothesize that
targeted prophylaxis and careful treatment of oral diseases can
prevent the progression of renal failure
Keywords: biochemical parameters, chronic kidney disease,
gingival recession, periodontitis.
References
1. Harvey, C.E. (2005) Management of periodontal disease:
Understanding the options. Vet Clin North Am Small Anim Pract.
35(4): 819-836.
http://dx.doi.org/10.1016/j.cvsm.2005.03.002
PMid:15979515 |
|
2. Calvert, C.A., Greene, C.E. and Hardie, E.M. (1985)
cardiovascular infections in dogs: epizootiology, clinical
manifestations, and prognosis. J Am Vet. Med. Assoc, 187(6):
612-616.
PMid:3910627 |
|
3. De Bowes, L.J., Mosier, D., Logan, E., Harvey, C.E., Lowry
S. and Richardson, D.C. (1996) Association of periodontal
disease and histopathologic lesions in multiple organs from 45
dogs. J Vet Dent. 13(2): 57-60. |
|
4. Dasanayake, A.P. (2009) C-reactive protein levels are
elevated in patients with periodontitis and their CRP levels
may go down after periodontal therapy. J Evid Based Dent Pract.
9:21–22.
http://dx.doi.org/10.1016/j.jebdp.2008.12.010
PMid:19269611 |
|
5. World Health Organization (WHO), (2011) Oral health
surveys, 5th edn. Geneva, p567-569. |
|
6. Jaffe, E.C. and Roberts, G.J. (1986) Dental findings in
chronic renal failure. Brit Dent. J. Hants, 160(1): p18-20.
http://dx.doi.org/10.1038/sj.bdj.4805752 |
|
7. Tollefsen, T. and Johansen, J.R. (1985) Periodontal status
in patients before and after renal allotransplantation. J
Periodont Res. 20: 227-236.
http://dx.doi.org/10.1111/j.1600-0765.1985.tb00430.x
PMid:3159880 |
|
8. Löe, H. Anerud, A. Boysen, H and Morrison E. (1967) Natural
history of periodontal disease in man. Rapid, moderate and no
loss of attachment in Sri Lankan laborers 14 to 46 years of
age. J Clin Periodontol. 13(5):431-45.
http://dx.doi.org/10.1111/j.1600-051X.1986.tb01487.x |
|
9. Oshrain, H.I., Mender, S. and Mandel, I.D. (1979)
Periodontal status of patients with reduced immunocapacity. J
Periodontol 50(4): 185-188.
http://dx.doi.org/10.1902/jop.1979.50.4.185
PMid:374705 |
|
10. Gorrel, C. and Bierer, T.L. (1999) Long term effects of a
dental hygiene chew on the periodontal health of dogs. J Vet
Dent, 16 (3) 109-113.
PMid:10863520 |
|
11. Loe, K.T. (2012) the neutrophil: Mechanisms of controlling
periodontal bacteria. J Periodontol, 62: 761-774. |
|
12. Kshirsagar, A.V., Bomback, A.S., Bang, H., Gerber, L.M.,
Vupputuri, S. and Shoham, D.A. (2008) Association of C -
reactive protein and micro albuminuria (from the National
Health and Nutrition Examination Surveys, 1999 to 2004). Am.
J. Cardiol. 101: 400–406.
http://dx.doi.org/10.1016/j.amjcard.2007.08.041
PMid:18237609 PMCid:PMC2848170 |
|
13. Scannapieco, F.A. and Panesar, M. (2008) Periodontitis and
chronic kidney disease. J. Periodontol. 79 (9):1617–1619.
http://dx.doi.org/10.1902/jop.2008.080313
PMid:18771360 |
|
14. Glickman, L.T., Glickman, N.W., Moore, G.E., Goldstein,
G.S. and Lewis, H.B. (2009) Evaluation of the risk of
endocarditis and other cardiovascular events on the basis of
the severity of periodontal disease in dogs. J. Am. Vet. Med.
Assoc.234 (4): 486–494.
http://dx.doi.org/10.2460/javma.234.4.486
PMid:19222358 |
|
15. De Bowes, L.J., Mosier, D., Logan, E., Harvey, C.E., Lowry
S. and Richardson, D.C. (1996) Association of periodontal
disease and histopathologic lesions in multiple organs from 45
dogs. J Vet Dent. 13(2): 57-60. |
|
16. Eisner, E.R. (1989) periodontal disease in pets: the
pathogenesis of a preventable problem. Vet. Med. Lenexa.
84(1): 97-104. |
|
17. Karjalainen, K. and Knuuttila, M. (1996) the onset of
diabetes and poor metabolic control increases gingival
bleeding in children and adolescents with insulin-dependent
diabetes mellitus. J Clin Periodontol, 23(12):1060-1067.
http://dx.doi.org/10.1111/j.1600-051X.1996.tb01804.x
PMid:8997648 |
|
18. Souza, C.M., Braosi, A.P.R. and Luczyszyn, S.M. (2010)
Association between vitamin D receptor gene polimor- phisms
and susceptibility to chronic kidney disease and periodontitis.
Blood Purifi. 25: 411-419.
http://dx.doi.org/10.1159/000109235
PMid:17914260 |
|
19. Yamalik, N. (1991) the histological investigation of
gingival from patients with chronic renal failure, renal
transplants, and periodontitis: A light and electron
microscopic study. J. Periodontol, Chicago, 62(12): 737- 744.
http://dx.doi.org/10.1902/jop.1991.62.12.737
PMid:1765936 |
|
20. Yoshihara, A., Seida, Y. and Hanada, N. (2010) A
longitudinal study of the relationship between periodontal
disease and bone mineral density in community-dwelling older
adults. J Clin. Periodontol. 31: 680-684.
http://dx.doi.org/10.1111/j.1600-051X.2004.00548.x
PMid:15257747 |
|
21. Taylor, G.W., Burt, B.A. and Becker, M.P (1998). Non-
insulin dependent diabetes mellitus and alveolar bone loss
progression over 2 years. J Periodontol 69(1):76-83.
http://dx.doi.org/10.1902/jop.1998.69.1.76
PMid:9527565 |
|
22. Wautier, J.L. and Guillausseau, P.J.(1998) Diabetes,
advanced glycation endproducts and vascular disease. Vasc
Med.3 (2):131-137.
http://dx.doi.org/10.1177/1358836X9800300207
PMid:9796076 |
|
23. Craig, R.G. (2008) Interactions between chronic renal
disease and periodontal disease. Oral Dis. 14: 1-7.
http://dx.doi.org/10.1111/j.1601-0825.2007.01430.x
PMid:18173441 |
|
24. Rahman, M.M., Çaglayan, F. and Rahman, B. (1992)
Periodontal health parameters in patients with chronic renal
failure and renal transplants receiving immunosuppressive
therapy. J. Dent., 34: 265-272. |
|
25. Glickman, L.T., (2011) Association between chronic
azotemic kidney disease and the severity of periodontal
disease in dogs. Pre. Vet. Med, 2011. 99(4): 193-200.
http://dx.doi.org/10.1016/j.prevetmed.2011.01.011
PMid:21345505 |
|