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R esearch
(Published online:
16-04-2015)
12.
Evaluation of biochemical alterations
produced by acetaminophen overdose in
Bubalus bubalis
-
Prashant Sudamrao
Daundkar and Suresh Kumar Sharma
Veterinary World, 8(4): 497-501
doi:
10.14202/vetworld.2015.497-501
Prashant Sudamrao Daundkar:
Department of Veterinary
Pharmacology and Toxicology, College of Veterinary Science, Guru
Angad Dev Veterinary and Animal Sciences University, Ludhiana,
Punjab, India;
prashant1985gadvasu@gmail.com
Suresh
Kumar Sharma: Department of Veterinary Pharmacology and
Toxicology, College of Veterinary Science, Guru Angad Dev
Veterinary
and Animal Sciences University, Ludhiana, Punjab, India;
sureshpau2000@yahoo.com
Received:
19-12-2014, Revised: 08-03-2015, Accepted: 14-03-2015, Published
online: 16-04-2015
Corresponding author:
Prashant Sudamrao Daundkar, e-mail: prashant1985gadvasu@gmail.com
Citation:
Daundkar PS, Sharma SK
(2015) Evaluation of biochemical alterations produced by
acetaminophen overdose in Bubalus bubalis, Veterinary
World 8(4): 497-501.
Abstract
Aim:
Evaluation of the effect of acetaminophen (APAP) overdose on
biochemical parameters in buffalo calves.
Materials and Methods: The experiment was conducted on six
healthy male buffalo calves of 6-12 months age. The APAP was
administered intramuscularly at the dose rate of 250 mg/kg body
weight (B.W.) on day 0, followed by two subsequent doses at the
dose rate of 50 mg/kg B.W. on day 2 and 4, respectively.
Biochemical parameters including alanine aminotransferase (ALT),
alkaline phosphatase (ALP), amylase, blood urea nitrogen (BUN),
creatinine, and total acid phosphate were estimated in the plasma
samples collected on 0, 1, 2, 3, 4, 5, and 6th day from the start
of treatment.
Results: Significant increase in the plasma levels of ALT
(446.0%), ALP (137%), BUN (216.8%) and creatinine (149.2%) was
recorded on day 3, 4, 3, and 4, respectively, after the start of
APAP dosing. However, a significant decrease was observed in
amylase activity with a maximum decline of 48.3% on 6th day after
the start of treatment. No significant alteration was observed in
ACP activity after APAP overdose.
Conclusion: Administration of APAP in overdose produced
hepatic dysfunction as evidenced by a significant increase in the
activities of ALT and ALP, whereas reduced amylase may indicate
acute pancreatitis in buffalo calves. In addition, repeated dosing
also resulted in renal impairment in these animals as seen by a
significant elevation in BUN and creatinine levels, whereas
negligible effect on prostatic function.
Keywords: acetaminophen, biochemical, buffalo calves, liver
dysfunction, renal impairment.
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