Open Access
Research
(Published
online: 14-11-2016)
12.
Relationship between hepcidin and
oxidant/antioxidant status in calves with suspected neonatal
septicemia -
E. E. Erkilic, H. M. Erdogan, M. Ogun, A. H. Kirmizigul, E. Gokce,
M. Kuru and A. Kukurt
Veterinary World, 9(11): 1238-1241
doi:
10.14202/vetworld.2016.1238-1241
E. E. Erkilic:
Department of Internal Medicine, Faculty of Veterinary Medicine,
University of Kafkas, 36100, Kars, Turkey; ekin_emre_24@hotmail.com
H. M. Erdogan:
Department of Internal Medicine, Faculty of Veterinary Medicine,
University of Kafkas, 36100, Kars, Turkey; hmerdogan@hotmail.com
M. Ogun:
Department of Biochemistry, Faculty of Veterinary Medicine,
University of Kafkas, 36100, Kars, Turkey; metinogun@hotmail.com
A. H. Kirmizigul:
Department of Internal Medicine, Faculty of Veterinary Medicine,
University of Kafkas, 36100, Kars, Turkey; ahkirmizigul@hotmail.com
E. Gokce:
Department of Internal Medicine, Faculty of Veterinary Medicine,
University of Kafkas, 36100, Kars, Turkey; erhangokce36@hotmail.com
M. Kuru:
Department of Obstetrics and Gynecology, Faculty of Veterinary
Medicine, University of Kafkas, 36100, Kars, Turkey; mushapkuru@hotmail.com
A. Kukurt:
Department of Biochemistry, Faculty of Veterinary Medicine,
University of Kafkas, 36100, Kars, Turkey; samedkukurt@gmail.com
Received: 05-08-2016, Accepted: 03-10-2016, Published online:
14-11-2016
Corresponding author:
E. E. Erkilic, e-mail: ekin_emre_24@hotmail.com
Citation:
Erkilic EE, Erdogan HM, Ogun M, Kirmizigul AH, Gokce E, Kuru M,
Kukurt A (2016) Relationship between hepcidin and
oxidant/antioxidant status in calves with suspected neonatal
septicemia,
Veterinary World, 9(11):
1238-1241.
Abstract
Aim:
This study has been conducted for the purpose of determining serum
hepcidin, total antioxidant status (TAS), total oxidant status (TOS),
and Fe levels in calves with suspected neonatal septicemia before
and after treatment and the clinical significance of hepcidin in
calves with suspected neonatal septicemia.
Materials and Methods:
The study material consisted of 15 calves of different ages and
sexes brought to the Training, Research and Application Center at
the Kafkas University Faculty of Veterinary Medicine with
suspected neonatal septicemia. 8.5 mL of blood was drawn from the
jugular vein of each animal into coagulant tubes before and after
treatment for one-off biochemical analyses and centrifuged. After
this, the serum was separated. Hepcidin, TAS, TOS, and Fe levels
in the serum were measured.
Results:
While pre-treatment hepcidin levels were 58.42±3.46 ng/mL,
post-treatment levels were 46.87±2.98 ng/mL (p<0.05).
Pre-treatment Fe levels were 60.13±7.27 μg/dl, while
post-treatment levels were 83.1±8.09 μg/dl (p<0.05). The changes
in the TAS and TOS levels were also found to be statistically
significant.
Conclusion:
In light of the fact that hepcidin plays a role function in the
regulation of Fe as well as the fact that Fe is a significant
nutritional source for many microorganisms, it was concluded that
hepcidin may play a significant role in nutritional immunity and
the pathogenesis of diseases.
Keywords:
Fe, hepcidin, oxidative stress, septicemia.
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