Open Access
Research
(Published
online: 24-10-2016)
16.
Impact of therapeutic and high doses of
florfenicol on kidney and liver functional indicators in goat -
Jan Muhammad Shah, Toufique Ahmed Qureshi, Tahmina Shah, Qurban
Ali Shah, Muhammad Asif Arain, Zohaib Ahmed Bhutto, Muhammad
Saeed and Farman Ali Siyal
Veterinary World, 9(10): 1135-1140
doi:
10.14202/vetworld.2016.1135-1140
Jan Muhammad Shah:
Department of Pharmacology, Shaheed Benazir Bhutto University of
Veterinary and Animal Sciences, Sakrand, Pakistan; dr.jm135@gmail.com
Toufique Ahmed Qureshi:
Department of Pharmacology, Shaheed Benazir Bhutto University of
Veterinary and Animal Sciences, Sakrand, Pakistan;
tofique_qureshi@hotmail.com
Tahmina Shah:
Department of Dairy Technology, Baqai College of Veterinary
Sciences, Baqai Medical University, Karachi, Pakistan;
vetdr.shah@gmail.com
Qurban Ali Shah:
Department of Animal Husbandry, Faculty of Veterinary and Animal
Sciences, Lasbela University of Agriculture, Water and Marine
Sciences, Uthal 3800, Pakistan; drshah73@yahoo.com
Muhammad Asif Arain:
Department of Animal Husbandry, Faculty of Veterinary and Animal
Sciences, Lasbela University of Agriculture, Water and Marine
Sciences, Uthal 3800, Pakistan; asifarain77@nwsuaf.edu.cn
Zohaib Ahmed Bhutto:
Department of Animal Husbandry, Faculty of Veterinary and Animal
Sciences, Lasbela University of Agriculture, Water and Marine
Sciences, Uthal 3800, Pakistan; bhutto92zohaib@gmail.com
Muhammad Saeed:
College of Animal Sciences and Technology, Northwest A & F
University, Yangling 712100, China; muhammad.saeed@nwsuaf.edu.cn
Farman Ali Siyal:
Department of Animal Nutrition, Faculty of Animal Husbandry and
Veterinary Sciences, Sind Agriculture University Tandojam,
Pakistan; drfarmansial@gmail.com
Received: 03-05-2016, Accepted: 01-09-2016, Published online:
24-10-2016
Corresponding author:
Jan Mohammad Shah, e-mail: dr.jm135@gmail.com
Citation:
Shah JM, Qureshi TA, Shah T, Shah QA, Arain MA, Bhutto ZA, Saeed
M, Siyal FA (2016) Impact of therapeutic and high doses of
florfenicol on kidney and liver functional indicators in goat,
Veterinary World, 9(10):
1135-1140.
Abstract
Aim:
The aim of this study was to evaluate the impact of therapeutic
and high doses of florfenicol on kidney and liver functional
indicators in goat species.
Materials and Methods:
Six mature, healthy goats (combine breed and sex) with average
weight 25 kg were selected for this study. The therapeutic (20
mg/kg b.w.) and high doses (40 and 60 mg) of florfenicol were
administered for 3 days with 24 h interval. Blood samples were
collected at 0, 24, 48, 72, 96, and 120 h following the each
administered dose.
Results:
The results showed that the therapeutic dose of florfenicol
produced nonsignificant effect on serum urea, creatinine, total
protein (TP), alkaline phosphatase (ALP), gamma-glutamyl
transferase (GGT) and bilirubin on all timings, and increased
(p<0.05) the serum glutamic oxaloacetic transaminase (SGOT) and
serum glutamate-pyruvate transaminase (SGPT) levels for 48 h.
Whereas the high doses of florfenicol (40 and 60 mg)
significantly altered the kidney and liver functional indicators
in the blood. In contrast with control, the serum urea level was
(p<0.01) increased at all timing points. Creatinine values were
altered (p<0.01, <0.05) in increasing manner from 24 to 96 h.
The high dose of 40 mg decreased the TP (p<0.05) for 72 h and 60
mg persisted same effect (p<0.01) up to 120 h. The indices of
ALP, GGT, SGOT, and SGPT were raised (p<0.01, <0.05) at all
timings. The bilirubin indexes also (p<0.05) elevated from 48 to
72.
Conclusion:
It was concluded that the high doses of florfenicol produced
reversible dose-dependent effects on functional indicators of
kidney and liver such as urea, creatinine, TP, ALP, SGOT, SGPT,
GGT, and bilirubin.
Keywords:
blood chemistry, florfenicol, goat, liver and kidney function
tests, therapeutic and high doses.
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