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Review
7. Highly
pathogenic avian influenza (HPAI) H5N1 virus in Asia: evolution
and vaccination -
Porntippa Lekcharoensuk
Vet World. 2008; 1(12): 368-374
Abstract
HPAI (H5N1) is
still an important emerging disease posing threat on both human
and animal health. The causative agent continues to evolve rapidly
within various poultry populations and may cause unpredictable
outcome. Evolution of the virus will continue until it reaches
equilibrium. At present, the HPAI (H5N1) viruses still possess
avian virus characteristics. However, if the viruses gain
opportunities to infect and evolve in human, it may accelerate
adaptation of the avian viruses to be more human preference and
thus acquires ability to infect and transmit efficiently among
human population. This review aims to elucidate crucial issues
regarding to role of vaccination in virus evolution including
influence of immune response after vaccination and adaptation of
virus to cross species. Additionally, role of vaccination in HPAI
(H5N1) control and drawback of vaccine usage are discussed.
Keywords: Avian
influenza virus, H5N1, evolution, interspecies transmission,
vaccination, disease control.
