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Research
8. Ameliorating
potential of ashwagandha on cadmium chloride induced changes in
weights of visceral organs -
A. U. Borde, A. M. Athawaley, M. S. Mendhe, M. K. Patil, P. R.
Lokhande, S. A. Jaiswal
Vet World. 2008; 1(11): 343-345
Abstract
The present study
was carried out to evaluate the protective effect of Ashwagandha
on Cadmium chloride induced changes in weights visceral organs of
male rats. Thirty male Wistar rats were divided equally into three
groups. Group I was fed on balanced diet of rat pellets for a
period of sixty days. The rats in-group II were given freshly
prepared cadmium chloride solution in the deionised drinking water
@200 ppm daily for 60 days. The rats in Group III were fed on
Ashwagandha plant powder thoroughly mixed in rat feed at the
concentration of 0.5g/Kg (w/w) corresponding to 500-ppm level.
Simultaneously the rats were given cadmium-chloride @200 ppm in
deionised drinking water throughout the experimental period. It is
concluded that oral administration of Ashwagandha plant powder for
60 days significantly improved the weights of testes, accessory
sex organs, liver and kidney in male rats. Simultaneous medication
of Ashwagandha (500 ppm in feed) reduced the severity of cadmium
chloride toxicity in male Wistar rats.
Keywords: Ashwagandha,
cadmium chloride, visceral organ, rat, liver, kidney.
