Histological changes of immediate skin expansion of the distal limb of rats

Vet World Vol.11 December-2018 Article-10

Research Article

Veterinary World, 11(12): 1706-1711

https://doi.org/10.14202/vetworld.2018.1706-1711

Ahmed Khalaf Ali^1,2, Adamu Abdul Abubakar¹, Ubedullah Kaka^1,3, Zamri Radzi⁴, Nurul Hayah Khairuddin⁵, Md Sabri Mohd Yusoff⁶, and Mohamad Yusof Loqman¹

1. Department of Companion Animal Medicine and Surgery, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
2. Department of Surgery and Theriogenology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq.
3. Institute of Tropical Agriculture and Food Security, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
4. Department of Paediatric Dentistry and Orthodontics, Faculty of Dentistry, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
5. Department of Farm and Exotic Animals Medicine and Surgery, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
6. Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

Background and Aim: Tissue expansion is an applicable technique to reconstruct many surgical defects. The aim of this research was to evaluate the histological changes caused by immediate skin tissue expansion in rats as an animal model.

Materials and Methods: Immediate skin tissue expansion in 18 adult female rats was performed using three different sizes (small, medium, and big) of polymethylmethacrylate tissue expanders at the dorsal surface of the metatarsal area of the right limb. The contralateral limb was served as the control. The tissue expanders were surgically implanted and kept for 15 days.

Results: The immediate skin expansion resulted in histological changes such as the increased thickness of the epidermal layer, the reduction of the dermal layer, an elevated number of fibroblast as well as increased vascularity. Furthermore, skin adnexal structures such as hair follicles and sebaceous glands were farther apart.

Conclusion: The rat skin was able to rapidly adjust and compensate against a specific range of immediate mechanical expansion. The histological changes suggest that the tissues were prepared to withstand the increased external forces, in addition to create possibly additional skin in a relatively short-term period. Keywords: histology, rats, skin expansion, tissue expander.

Keywords: histology, rats, skin expansion, tissue expander.

How to cite this article: Ali AK, Abubakar AA, Kaka U, Radzi Z, Khairuddin NH, Yusoff MSM, Loqman MY (2018) Histological changes of immediate skin expansion of the distal limb of rats, Veterinary World, 11(12): 1706-1711.

Received: 12-07-2018 Accepted: 15-10-2018 Published online: 20-12-2018

Corresponding author: Mohamad Yusof Loqman E-mail: myloqman@gmail.com

DOI: 10.14202/vetworld.2018.1706-1711

Copyright: Ali, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.