Vet World Vol.11 June-2018 Article-19
Review Article
Veterinary World, 11(6): 852-858
https://doi.org/10.14202/vetworld.2018.852-858
Insights into pH regulatory mechanisms in mediating spermatozoa functions
2. Department of Gynaecology and Obstetrics, College of Veterinary Sciences and Animal Husbandry, U.P. Pandit Deendayal Upadhayaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan, Mathura - 281 001, Uttar Pradesh, India.
3. Department of Physiology, College of Veterinary Sciences and Animal Husbandry, U.P. Pandit Deendayal Upadhayaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan, Mathura - 281 001, Uttar Pradesh, India.
Background and Aim: Regulation of pH in spermatozoa is a complex and dynamic process as sperm cells encounter different pH gradients during their journey from testes to the site of fertilization in female genital tract. The precise regulations of pH in sperm cells regulate the sperm functions such as motility, hyperactivity, capacitation, and acrosome reaction. Electrophysiological, pharmacological, and molecular studies have revealed the presence of different ion channels and exchanger systems which regulate intracellular pH in sperm cells as well as regulate sperm functions. Recent studies also have shown the potential involvement of pH in the regulation of fertility competence of sperm cells, and alterations in pH have shown to impede sperm functions. This mini-review discusses the probable mechanisms involved in pH regulation in sperm cells and how pH is involved in regulation of various sperm functions.
Keywords: acrosome reaction, capacitation, fertilization, pH, sperm motility, spermatozoa.
How to cite this article: Mishra AK, Kumar A, Swain DK, Yadav S, Nigam R (2018) Insights into pH regulatory mechanisms in mediating spermatozoa functions, Veterinary World, 11(6): 852-858.
Received: 13-02-2018 Accepted: 17-05-2018 Published online: 26-06-2018
Corresponding author: Dilip Kumar Swain E-mail: dilip_swain@yahoo.com
DOI: 10.14202/vetworld.2018.852-858
Copyright: Mishra, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.