Vet World   Vol.12   May-2019  Article-9

Golden sea cucumber extract revives glucose transporter-4 and interleukin-6 protein level in diabetic mouse muscle

Background and Aim: This study was aimed to investigate the effect of golden sea cucumber extract on PC, IL-6, and Glut-4 level of STZ-induced diabetes mouse.

Materials and Methods: This study was performed using mice, which were grouped into non-diabetes, diabetes, and diabetes-treated extract groups. The golden sea cucumber was extracted using 70% ethanol, which was administered by oral gavage twice a day for 5 consecutive days.

Results: The extract reduced PC level and improved muscle Glut-4 and IL-6 protein level of diabetic mouse.

Conclusion: The extract of golden sea cucumber revived muscle Glut-4 and IL-6 protein level in protection against muscle wasting. Keywords: diabetes, glucose transporter, interleukin, muscle.

Keywords: diabetes, glucose transporter, interleukin, muscle.

How to cite this article: Purwanto B, Wiyasihati SI, Masyitha PA, Wigati KW, Irwadi I (2019) Golden sea cucumber extract revives glucose transporter-4 and interleukin-6 protein level in diabetic mouse muscle, Veterinary World, 12(5): 684-688.

Received: 06-12-2018  Accepted: 22-03-2019     Published online: 18-05-2019

Corresponding author: Irfiansyah Irwadi   E-mail: irfiansyah@fk.unair.ac.id

DOI: 10.14202/vetworld.2019.684-688

Copyright: Purwanto, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.