Research Article | 18 May 2019

Golden sea cucumber extract revives glucose transporter-4 and interleukin-6 protein level in diabetic mouse muscle

Bambang Purwanto1, Sundari Indah Wiyasihati1, Putri Ayu Masyitha2, Kristanti Wanito Wigati1, and Irfiansyah Irwadi1Show more
VETERINARY WORLD | pg no. 684-688 | Vol. 12, Issue 5 | DOI: 10.14202/vetworld.2019.684-688
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Abstract

          
Background and Aim: This study was aimed to investigate the effect of golden sea cucumber extract on PC, IL-6, and Glut-4 level of STZ-induced diabetes mouse.
Materials and Methods: This study was performed using mice, which were grouped into non-diabetes, diabetes, and diabetes-treated extract groups. The golden sea cucumber was extracted using 70% ethanol, which was administered by oral gavage twice a day for 5 consecutive days.
Results: The extract reduced PC level and improved muscle Glut-4 and IL-6 protein level of diabetic mouse.
Conclusion: The extract of golden sea cucumber revived muscle Glut-4 and IL-6 protein level in protection against muscle wasting. Keywords: diabetes, glucose transporter, interleukin, muscle.
          
Keywords: diabetes, glucose transporter, interleukin, muscle.