Vet World   Vol.13   April-2020  Article-5

Coenzyme Q10 coadministration with diclofenac augmented impaired renal function in broiler chickens (Gallus gallus domesticus)

Background and Aim: This study aimed to investigate the effects of coenzyme Q10 (COQ10) and diclofenac coadministration on the hepatorenal function in broiler chickens (Gallus gallus domesticus).

Materials and Methods: Birds (21 days old) were divided into six groups of eight birds each. The 1st group was the control, the 2nd group was treated orally with COQ10 (30 mg/kg b.wt), the 3rd and 4th groups were treated intraperitoneally with diclofenac sodium at doses 1 and 2 mg/kg b.wt, respectively, and the 5th and 6th groups were treated with COQ10 (dose 30 mg/kg b.wt, P.O.) and diclofenac sodium (dose 1 mg/kg b.wt, I.P.) and COQ10 (dose 30 mg/kg b.wt, P.O.) and diclofenac sodium (dose 2 mg/kg b.wt, I.P.), respectively. The experiment lasted 5 days. Twenty-four hours after the last administration, all the birds were sacrificed through cervical dislocation; blood samples were collected for serum biochemical analysis.

Results: COQ10 induced a significant increase in aspartate aminotransferase (AST), urea, creatinine, sodium, potassium, and chloride, while diclofenac induced a significant increase in alanine aminotransferase (ALT), AST, total cholesterol, triglyceride, high-density lipoprotein, urea, creatinine, sodium, potassium, and chloride. However, when COQ10 and diclofenac were coadministered, we observed that COQ10 decreased the liver injury caused by diclofenac. However, COQ10 could not relieve the kidney injury caused by diclofenac, but worsened the impaired renal function.

Conclusion: COQ10 protects the liver against diclofenac-induced liver injury while augmenting diclofenac-induced kidney injury. Keywords: broiler, coadministration, COQ10, diclofenac, kidney liver.

Keywords: broiler, coadministration, COQ10, diclofenac, kidney liver.

How to cite this article: Albadrany Y, Naser A (2020) Coenzyme Q10 coadministration with diclofenac augmented impaired renal function in broiler chickens (Gallus gallus domesticus), Veterinary World, 13(4): 642-648.

Received: 02-12-2019  Accepted: 24-02-2020     Published online: 10-04-2020

Corresponding author: Yasser Albadrany   E-mail: yasseralbadrany@yahoo.com

DOI: 10.14202/vetworld.2020.642-648

Copyright: Albadrany and Naser, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.