Vet World   Vol.13   March-2020  Article-5

Hematological and serum biochemical profile in cattle experimentally infected with foot-and-mouth disease virus

Background and Aim: Foot-and-mouth disease (FMD) is an acute viral infection affecting cloven-hoofed animals causing vesicular erosions in the oral cavity and interdigital space. The present study was undertaken to ascertain the time-dependent changes in clinical, hematological, and biochemical profiles in different breeds of cattle following experimental infection.

Materials and Methods: The animals were inoculated with 1.0×104 50% bovine tongue infectious dose (BTID50) by intradermolingual route. Clinical signs were observed, and blood/serum samples were collected at different time intervals.

Results: The white blood cell count declined sharply on days 7-13 and recovered on day 14 post-FMD infection. Biochemical analysis of serum markers for vital organ profile revealed no marked damage. However, a significant increase in blood urea nitrogen (BUN) value indicated pre-renal azotemia. Transient hyperthyroidism was indicated by the rise in T3 and T4 that can be correlated with a decrease in triglyceride and total cholesterol levels. In the cardiac damage assessment study, a distinct breed difference was observed wherein Malnad Gidda calves showed no cardiac damage.

Conclusion: Except thyroid profile, BUN, and creatine kinase-myocardial band, all other serum biochemical parameters showed no significant abnormalities, whereas lymphopenia is the only hematological change and it is suggested that effective ameliorative measures should be targeted mainly on the feed/water intake, thyroid gland, and the level of lymphocytes. Keywords: biochemical profile, experimentally infected indigenous and crossbred calves, foot-and-mouth disease, hematological profile.

Keywords: biochemical profile, experimentally infected indigenous and crossbred calves, foot-and-mouth disease, hematological profile.

How to cite this article: Saravanan S, Umapathi V, Priyanka M, Hosamani M, Sreenivasa BP, Patel BHM, Narayanan K, Sanyal A, Basagoudanavar SH (2020) Hematological and serum biochemical profile in cattle experimentally infected with foot-and-mouth disease virus, Veterinary World, 13(3): 426-432.

Received: 04-12-2019  Accepted: 20-01-2020     Published online: 09-03-2020

Corresponding author: S. H. Basagoudanavar   E-mail: surbh2001@gmail.com

DOI: 10.14202/vetworld.2020.426-432

Copyright: Saravanan, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.