Association of bovine uterine involution disturbances with serum neuropeptide concentrations

Vet World Vol.13 September-2020 Article-14

Research Article

Veterinary World, 13(9): 1854-1857

https://doi.org/10.14202/vetworld.2020.1854-1857

Aida Abultdinova¹, Isatay Jakupov¹, Joachim Roth², Klaus Failing³, Axel Wehrend⁴, and Marlene Sickinger⁵

1. Department of Veterinary Medicine, Faculty of Veterinary Medicine and Technology of Animal Husbandry, S. Seifullin Kazakh Agro Technical University, Nur-Sultan, Kazakhstan.
2. Institute of Veterinary Physiology, Justus Liebig University Giessen, Germany.
3. Biomathematics and Data Processing Unit, Justus Liebig University Giessen, Germany.
4. Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals with Veterinary Ambulance, Justus Liebig University Giessen, Germany.
5. Clinic for Ruminants Internal Medicine and Surgery, Justus Liebig University Giessen, Germany.

Background and Aim: Puerperal diseases influence fertility and should be diagnosed as soon as possible. This study aimed to evaluate the applicability of serum concentrations of substance P (SP), vasoactive intestinal polypeptide (VIP), and interleukin (IL)1β in the early diagnosis of uterine involution disturbances.

Materials and Methods: Blood serum samples of 86 dairy cows from six different farms were harvested within the first 20 days after calving from cows with uterine involution disturbances and healthy controls, respectively. Serum concentrations for SP, VIP, and IL-1β were determined using commercially available ELISA test kits. Statistical analyses included timely changes in blood serum levels and group comparisons of healthy cows and cows with uterine disease.

Results: SP concentrations increased significantly within 20 days after calving (p<0.04) with no significant difference observed between the groups. Moreover, no significant differences were found between VIP and log IL-1β.

Conclusion: Results showed that none of the examined serum parameters seems suitable as indicator of uterine involution disorders. Due to the timely changes in serum concentrations of SP after calving, a correlation to diseases might not be precluded. Further research is needed as regards the establishment of normative values concerning this parameter. Keywords: dairy cow, diagnostics, inflammation, neuropeptides, uterus involution.

Keywords: dairy cow, diagnostics, inflammation, neuropeptides, uterus involution.

How to cite this article: Abultdinova A, Jakupov I, Roth J, Failing K, Wehrend A, Sickinger M (2020) Association of bovine uterine involution disturbances with serum neuropeptide concentrations, Veterinary World, 13(9): 1854-1857.

Received: 18-03-2020 Accepted: 24-07-2020 Published online: 11-09-2020

Corresponding author: Marlene Sickinger E-mail: Marlene.Sickinger@vetmed.uni giessen.de

DOI: 10.14202/vetworld.2020.1854-1857

Copyright: Abultdinova, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.