Vet World   Vol.14   January-2021  Article-22

Effects of tissue-specific biomolecules on piglets after-weaning period

Background and Aim: Now-a-days antibiotics are the main tool for correcting the pathological conditions of pigs; unfortunately, antibiotics are a potential threat to the environment, as they lead to the spread of antibiotic-resistant infections. This study aimed to study the immunomodulatory encapsulated biomolecules on piglets in the post-weaning period.

Materials and Methods: An immunomodulator based on biomolecules obtained from animal raw materials included in alginate capsules to improve absorption has been developed. The study presents the results of a study on 25 weaned piglets (25-30 days old) which received biomolecules at a dose of 200 mg/piglet for 14 days, followed by 400 mg/piglet from days 15 to 28. Blood was taken from animals for analysis (biochemical, hematological, cytometric, and enzyme immunoassay) and the integral index of blood serum antimicrobial activity was determined.

Results: Experimental animals, whose initial weight was 1.6 times less than that of the control animals, were able to bridge this gap and, on the 28th day, there were no differences in weight. Stimulation of the production of cytokines interleukin (IL)-2 and IL-4 was observed and the antimicrobial resistance of blood serum to Escherichia coli also increased. A positive effect on the metabolism of piglets was noted, which helped them adapt to a change in diet (from colostrum to solid food).

Conclusion: The results show that the immunomodulation at the dose of 150 mg/kg body weight has a great potential for improving weaned pigs. Keywords: biomolecules, health, immune system, pig, sustainable pork production.

Keywords: biomolecules, health, immune system, pig, sustainable pork production.

How to cite this article: Vasilevskaya ER, Fedulova LV, Chernukha IM, Kotenkova EA, Fokina AI (2021) Effects of tissue-specific biomolecules on piglets after-weaning period, Veterinary World, 14(1): 168-175.

Received: 04-09-2020  Accepted: 01-12-2020     Published online: 21-01-2021

Corresponding author: Ekaterina Romanovna Vasilevskaya   E-mail: rina715@yandex.ru

DOI: 10.14202/vetworld.2021.168-175

Copyright: Vasilevskaya, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.