Demographic and clinical characteristics of dogs with centroblastic lymphoma

Vet World Vol.14 January-2021 Article-6

Research Article

Veterinary World, 14(1): 49-55

https://doi.org/10.14202/vetworld.2021.49-55

Katarzyna Kliczkowska-Klarowicz¹, Dariusz Jagielski², Michał Czopowicz³, and Rafał A. Sapierzyński¹

1. Department of Pathology and Veterinary Diagnostics, Division of Pathology, Institute of Veterinary Medicine, Warsaw University of Life Sciences (SGGW), Nowoursynowska 159c, 02-776 Warsaw, Poland.
2. Białobrzeska Veterinary Surgery in Warsaw, Poland.
3. Division of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences (SGGW), Nowoursynowska 159c, 02-776 Warsaw, Poland.

Background and Aim: Centroblastic lymphoma (CBL) is the most common morphological type of lymphoma found in dogs; it is usually identified through cytology in veterinary clinical practice. This study aimed to identify the demographic and clinical characteristics of dogs with CBL that was diagnosed with cytology and immunocytochemistry.

Materials and Methods: Dogs with a suspicion of lymphoma were diagnosed by cytology supported by immunocytochemistry with the use of the updated Kiel classification adapted for dogs. During the analyzed time period, 336 lymphomas were diagnosed in dogs, including 171 cases of CBL. Epidemiological and clinical data from the dogs with CBL were provisionally collected.

Results: The epidemiology analysis revealed an increased risk of CBL in Rottweilers, golden retrievers, and Bernese mountain dogs. At admission, most of the dogs displayed generalized lymphadenopathy with spleen and liver enlargement. The most common hematological abnormality was leukocytosis due to neutrophilia. The most common biochemical abnormality was elevated alanine aminotransferase and alkaline phosphatase activities and selective hypoproteinemia due to hypoalbuminemia.

Conclusion: Rottweilers, Bernese mountain dogs, and golden retrievers appear to be overrepresented among dogs with CBL. CBL is usually diagnosed at an advanced clinical stage according to the World Health Organization; however, it is usually accompanied by only minor hematological and biochemical abnormalities. Keywords: Bernese mountain dogs, clinical stage, cytology, epidemiology, fine-needle biopsy, Golden Retrievers, immunophenotype, lymphoma, Rottweilers.

Keywords: Bernese mountain dogs, clinical stage, cytology, epidemiology, fine-needle biopsy, Golden Retrievers, immunophenotype, lymphoma, Rottweilers.

How to cite this article: Kliczkowska-Klarowicz K, Jagielski D, Czopowicz M, Sapierzyński RA (2021) Demographic and clinical characteristics of dogs with centroblastic lymphoma, Veterinary World, 14(1): 49-55.

Received: 17-07-2020 Accepted: 24-11-2020 Published online: 07-01-2021

Corresponding author: Katarzyna Kliczkowska-Klarowicz E-mail: katarzyna_kliczkowska@sggw.edu.pl

DOI: 10.14202/vetworld.2021.49-55

Copyright: Kliczkowska-Klarowicz, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.