Vet World Vol.14 June-2021 Article-4
Research Article
Veterinary World, 14(6): 1426-1429
https://doi.org/10.14202/vetworld.2021.1426-1429
Optimal therapeutic adropin dose intervention in mice and rat animal models: A systematic review
2. Basic Veterinary Sciences, School of Veterinary Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Background and Aim: Adropin is a hormone encoded by the Enho gene, which is associated with energy homeostasis. Preclinical studies using animal models have shown that adropin plays a role in enhancing glucose homeostasis and dyslipidemia. Lately, several studies on animal models have been performed to examine the therapeutic and pathophysiological effects of adropin in many disorders. The aim of this systematic review was to identify the ideal adropin dose in mice and rat animal models.
Materials and Methods: We systematically searched PubMed, Science Direct, and Scopus databases from 2008 to 2020. The terms used in the search were "adropin," "adropin doses in animal models," "glucose homeostasis related to adropin," and "adropin therapeutic effects on rats and mice." Articles that included non-adropin doses, in vitro studies, and factors affecting adropin levels were excluded from the study.
Results: Of the total 179 qualified studies, six studies were included. We found that a daily injection of 450 nmol/kg of adropin for 3 days might be considered the optimum dose of effect in mice, whereas injection of 2.1 μg/kg once a day for 10 successive days might be the optimal effective dose in rats.
Conclusion: Additional investigations are needed to determine the optimum dose of adropin to be used as a therapeutic intervention depending on the animal model. Keywords: adropin, animal model, dyslipidemia, glucose homeostasis, systematic review, therapeutic dose.
Keywords: adropin, animal model, dyslipidemia, glucose homeostasis, systematic review, therapeutic dose.
How to cite this article: Alzoughool F, Al-Zghoul MB (2021) Optimal therapeutic adtropin dose intervention in an animal model: A systematic review, Veterinary World, 14(6): 1426-1429.
Received: 13-01-2021 Accepted: 26-04-2021 Published online: 04-06-2021
Corresponding author: Mohammad Borhan Al-Zghoul E-mail: alzghoul@just.edu.jo
DOI: 10.14202/vetworld.2021.1426-1429
Copyright: Alzoughool and Al-Zghoul, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.