Vet World Vol.14 November-2021 Article-11
Research Article
Veterinary World, 14(11): 2919-2928
https://doi.org/10.14202/vetworld.2021.2919-2928
Efficacy of Dipterocarpus alatus oil combination with Rhinacanthus nasutus leaf and Garcinia mangostana pericarps against canine demodicosis
2. Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand.
3. Department of Community Health, Faculty of Public Health, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon 47000, Thailand.
4. Program in Animal Science, Faculty of Agricultural Technology, Sakon Nakhon Rajabhat University, Sakon Nakhon 47000, Thailand.
5. Department of Traditional Medicine, Faculty of Natural Resources, Rajamangala University of Technology ISAN Sakon Nakhon Campus, Sakon Nakhon 47160, Thailand.
6. Department of Community Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
7. Department of Anesthesiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
8. Department of Parasitology, Gifu University School of medicine, Gifu 501-1194, Japan.
Background and Aim: Canine demodicosis is a skin disease that is a major global health problem in dogs. Ivermectin is a drug of choice for treatment, but it may cause toxicity in dogs carrying multidrug resistance mutation-1 gene mutations. Hence, alternative herbal medicines are used instead of the drug, such as Dipterocarpus alatus oil (YN oil), Rhinacanthus nasutus leaf (WC), and Garcinia mangostana pericarps (MG) extracts. This study aimed to determine the efficacy of D. alatus oil, R. nasutus leaf, and G. mangostana pericarp extracts on canine demodicosis in vivo.
Materials and Methods: Twenty-five mixed-breed dogs with localized demodicosis were examined. Dogs were diagnosed with demodicosis through deep skin scraping and screened with the inclusion criteria. Five dogs of each group were treated in five treatment groups (ivermectin, YN oil, YN oil+WC, YN oil+MG, and YN oil+WC+MG) for 1 month. The individual dogs were clinically evaluated, and the dermatological lesions were monitored daily for 60 days.
Results: Dermatological lesion improvement was predominantly observed in the group of dogs treated with YN oil+WC. This was evidenced by the disappearance of the hyperpigmentation and lichenification on day 28 post-treatment and alopecia on day 56 post-treatment. Moreover, no allergic or clinical signs were observed during treatment.
Conclusion: YN oil+WC is an alternative herbal medicine that could be used for the treatment of localized canine demodicosis. Keywords: demodicosis, Dipterocarpus alatus, mangosteen pericarp, treatment, white crane flower.
Keywords: demodicosis, Dipterocarpus alatus, mangosteen pericarp, treatment, white crane flower.
How to cite this article: Artchayasawat A, Boueroy P, Boonmars T, Pumhirunroj B, Sriraj P, Aukkanimart R, Boonjaraspinyo S, Pitaksakulrat O, Ratanasuwan P, Suwannatrai A, Eamudomkarn C, Laummaunwai P, Zhiliang W (2021) Efficacy of Dipterocarpus alatus oil combination with Rhinacanthus nasutus leaf and Garcinia mangostana pericarps against canine demodicosis,Veterinary World, 14(11): 2919-2928.
Received: 04-07-2021 Accepted: 07-10-2021 Published online: 16-11-2021
Corresponding author: Thidarut Boonmars E-mail: bthida@kku.ac.th
DOI: 10.14202/vetworld.2021.2919-2928
Copyright: Artchayasawat, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.