Open Access
Copyright: The authors. This article is an open access
article licensed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/2.0) which permits unrestricted use,
distribution and reproduction in any medium, provided the work is properly
cited.
Research
4.
Safety level of levofloxacin following repeated oral
adminstration in white leg horn layer birds -
Jatin H. Patel, Rasesh D. Varia, Urvesh D. Patel, Priti D. Vihol,
Shailesh K. Bhavsar and Ashwin M. Thaker
Vet World. 2009; 2(4): 137-139
Abstract
Levofloxacin is a fluorinated quinolone which has broad-spectrum
antibacterial activity at low plasma/tissue concentration. The
present study was designed to investigate safety of levofloxacin
(10 mg/kg) after repeated oral administration at 12 hours
interval for 14 days in layer birds (30-35 weeks old and
weighing between 1.5-2.0 kg) and to determine tissue
concentration of the drug following oral administration (10
mg/kg) for 5 days. Drug concentration in tissue was determined
using High Performance Liquid Chromatography (HPLC). Repeated
oral administration of levofloxacin in layer birds was found
safe based on evaluation of haematological (Hb, PCV, TLC and DLC),
blood biochemical (AST, ALT, AKP, ACP, LDH, BUN, Serum total
protein, Serum albumin, Serum Creatinine, Blood glucose and
Total bilirubin) and histopathology of liver, kidney and joint
cartilage. Levofloxacin could not be detected in body tissues
(liver and skeletal muscle) at 12 hours after the last
administration.
Key words:
Levofloxacin, Safety, Repeated oral administration, Layer birds
