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Research
8.
Efficacy of Pcroriza kurrooa benth in experimentally
induced Hepato-toxicity in cross-bred calves -
V. R. Talmale, P. R. More, B. C. Ghumare, S. B. Shendre and S.
N. Nirgulkar
Vet World. 2010; 3(1): 29-31
Abstract
Alcoholic
extract of roots of picrorhiza kurrooa Benth was
screened for its photochemical & hepato protective
activity by metabolic (biochemical) profile for hepato-protective
activity by invasive blood sampling in calves. The mean
extractability percentage obtained was 40.5. Phyto-chemical
study revealed that the presence of reducing sugar, glycosides & saponins.
The level of SGOT (AST), SGPT (ALT), alkaline phosphates, bilirubin increased
significantly while the level of protein, albumin, globulin and
glucose decreased significantly and moderate but not significant
increase in cholesterol level in serum in calves treated with
CC14 (thrice a week for two weeks, intra ruminally)
were observed. The bio-chemical alterations might be due to
damage of liver cells and impairment in its functions. The
animals treated with alcoholic extract 10 & 15 mg/kg Body wt. For
14 days by oral route afforded a significant protection against
biochemical alterations induced by carbon tetrachloride. Thus
the efficient protection of calves to varying degree, by the
alcoholic extract of Picrorhiza kurrooa Benth given
with carbon tetrachloride was observed from the clinical &
biochemical investigations.
Keywords: Hepato-toxicity, Alchoholic Extract,
Biochemical.
