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Research
6.
Hematobiochemical changes of lead poisoning and
amelioration with Ocimum sanctum in wistar
albino rats -
Sujatha K. Karamala,
Ch Srilatha, Y. Anjaneyulu, T. S. ChandraSekharaRao,
D. Sreenivasulu, Amravathi P. Pidugu
Vet World. 2011; 4(6): 260-263
doi:
10.5455/vetworld.4.260
Abstract
An experiment was carried out to study the
hematobiochemical changes of chronic lead poisoning
in adult male wistar albino rats for a period of
twelve weeks. Adult 216 healthy rats were randomly
divided into six groups viz. control (groupI),
higher dose of lead acetate @60mgs/kg bwt (group
II), Lower dose of lead acetate @ 30 mgs / kg bwt
(group III), Higher dose of lead + Ocimum @ 400 mgs/
kg bwt (group IV), lower dose of lead + Ocimum @ 400
mgs/ kg bwt (group V), Ocimum control (group VI).
All lead treated and ameliorated groups given Lead
acetate/ lead + Ocimum orally for three days in a
week for a period of twelve weeks. The mean PCV, Hb,
values were reduced significantly (P<0.05) in lead
treated rats as dose dependent manner. Where as
significant improvement was noticed in Ocimum
treated groups Increased TLC and PLC values as dose
dependent manner. A significant reduction in PNC was
noticed in ocimum treated groups. Significant
(P<0.05) decrease in serum total protein values,
serum glucose and increased creatinine values were
observed in lead treated groups as dose dependent .
Increased protein & glucose and decreased creatinine
values obtained in Ocimum treated groups. The
alterations in hematological and biochemical
parameters in the present study indicates decreased
lifespan & fragility of RBC and damage to liver,
kidney and Pancreas in lead poisoned wistar albino
rats.
Keywords: Lead poisoning,
hematobiochemical alterations, Ocimum amelioration,
wistar rats
