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Research
4.
In vivo trypanocidal
activity of Hydroethanolic extract of Hymenocardia
acida stem bark in rats -
Hyacinth Abu Adakole, Chukwuka N. Uchendu
Vet World. 2011; 4(3): 113-116
doi:
10.5455/vetworld.2011.113-116
Abstract
The in vivo trypanocidal efficacy of Hydroethanolic
extract of Hymenocardia acida stem bark was
evaluated in Wistar rats. Three groups of rats were
treated orally with the extract at doses of 100, 200
and 400 mg/kg body weight for 6 days. Two other
groups received the vehicle and Diminazene accurate
at 3.5 mg/kg to serve as negative and positive
control respectively. The mean survival period of
infected animals, daily level of parasitaemia,
packed cell volume, total and differential leukocyte
counts were evaluated. Oral administration of the
extract did not significantly (P > 0.05) affect the
packed cell volume. However, the extract reduced the
level of parasitaemia and prolonged the life span of
infected rats. This study shows in vivo potential of
hydroethanolic extract of H. acida in the treatment
of African trypanosomosis.
Key words: Albino
rats, Trypanocidal, Hymenocardia acida, Herbal drug,
Parasitemia, African Trypanosomiasis.
