Open Access
Copyright: The authors. This article is an open access
article licensed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/2.0) which permits unrestricted use,
distribution and reproduction in any medium, provided the work is properly
cited.
Review Article
11.
Cardiac troponin: an emerging cardiac biomarker in
animal health -
Vishal V. Undhad, Dhaval T. Fefar, B. M. Jivani,
Hemant Gupta, Dineshbhai J. Ghodasara, Bholanath P.
Joshi, Kantibhai S. Prajapati
Vet World. 2012; 5(8): 508-511
doi:
10.5455/vetworld.2012.508-511
Abstract
Analysis of
cardiac troponin I (cTn I) and T (cTnT) are
considered the “gold standard” for the non-invasive
diagnosis of myocardial injury in human and animals.
It has replaced traditionally used cardiac
biomarkers such as myoglobin, lactate dehydrogenase
(LDH), creatine kinase (CK) and CK-MB due to its
high sensitivity and specificity for the detection
of myocardial injury. Cardiac troponins are proteins
that control the calcium-mediated interaction
between actin and myosin, allowing contraction at
the sarcomere level. Concentration of the cTn can be
correlated microscopic lesion and loss of
immunolabeling in myocardium damage. Troponin
concentration remains elevated in blood for 1-2wks
so that wide window is available for diagnosis of
myocardial damage. The cTn test has >95% specificity
and sensitivity and test is less time consuming (10
to 15 minutes) and less costly (INR 200 to INR 500).
Keywords: Cardiac troponin C, I and T,
myocardium, cardiac biomarkers
