|
|
Open Access
Copyright: The authors. This article is an open access
article licensed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/2.0) which permits unrestricted use,
distribution and reproduction in any medium, provided the work is properly
cited.
Original Research
1.
Efficacy of leptospiral vaccine (vax-SPIRAL®)
against challenge with strains isolated from
leptospirosis epidemic in Nicaragua using the
hamster as biomodel -
Luis Alfredo Rosario Fernández, Niurka Batista
Santiesteban, Daniel Francisco Arencibia Arrebola,
Bárbara Yolanda Valdés Abreú, Willian Jirón Toruño
and Chistyane Duttman
Vet World. 2012; 5(1): 5-12
doi:
10.5455/vetworld.201 2.5-12
Abstract
A hamster model was used to determine the
protector capacity of vax-SPIRAL® against the
lethal infection after challenge with 10,000 LD50
of four strains isolated of a leptospirosis
outbreaks in Nicaragua. These strains were
selected from a primary group of 16 belonging to
the serogroups strains Ballum, Icterohemorragiae,
Pomona, Serjoe and Pyrogenes. Most of these,
except Pyrogenes serogroup, reproduced the
infection in animal model and the most virulent
representatives of each serogroup were selected
for the challenge. The results of this study
suggest that vax-SPIRAL® conferred high percents
of heterologous protection which aimed to consider
it as a prophylactic measure useful in situations
of floods and natural disasters in Nicaragua.
Keywords: Leptospira, Heterologous protection,
Natural Disaster, Biomodel, Endemic disease,
Serogroup.
|
|
