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Original Research
7.
Haemato-biochemical alterations induced by diclofenac sodium toxicity in
swiss albino mice -
Basavraj S. Thanagari, Dhaval T. Fefar, Kantibhai S.
Prajapati, B. M. Jivani, Ketan B. Thakor, Jatin H.
Patel, Dineshbhai J. Ghodasara, Bholanath P. Joshi,
Vishal V. Undhad
Vet World. 2012; 5(7): 417-419
doi:
10.5455/vetworld.2012.41
7-419
Abstract
Aim:
An experiment was conducted to study the haemato-biochemical
alterations induced by Diclofenac Sodium toxicity.
Materials and Methods: 48 Swiss albino mice
of either sex, divided uniformly into four different
groups. The mice of group I received only deionised
water as control while, group II, III and IV were
given Diclofenac sodium @ 2.37 mg/kg B.W, 4.75 mg/kg
B.W, 9.5 mg/kg B.W orally for 28 days.
Results:
In dose dependant significant reductions in TEC, Hb,
PCV, MCV, MCHC were observed. No significant change
was observed in total WBC count in both the sexes.
However, relative values of leukocytes indicated
relative neutrophilia and relative lymphopenia in
higher group. Biochemically dose dependant
significant changes were observed for AST, ALT,
Total bilirubin, Total protein, Albumin, Globulin,
Cholesterol, Urea, Creatinine and Uric acid in male
and female animals.
Conclusion: The present
study indicates hepatobilliary, nephric and
gastrointestinal toxicity in albino swiss mice due
to Diclofenac Sodium Toxicity.
Keywords:
Biochemical, Haematology, Diclofenac sodium, Mice
