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Original Research
9.
Pharmacokinetics and bioavailability of
tulathromycin following intravenous, intramuscular
and subcutaneous administrations in healthy rabbits -
K Abo-El-Sooud, N A Afifi, A M Abd El-Aty
Vet World. 2012; 5(7): 424-428
doi:
10.14202/vetworld.2012.424-428
Abstract
Aim:
This work was performed to investigate the
pharmacokinetics of the triamilide antibiotic,
tulathromycin in healthy rabbits.
Materials and
Methods: Ten rabbits in each group were given a
single dose of 2.5 mg/kg body weight (bw) of
tulathromycin via intravenous (IV), intramuscular
(IM) and subcutaneous (SC) administrations. The
concentration of tulathromycin in plasma was
determined by microbiological assay Bacillus
subtilis ATCC 6633 as the test organism.
Results:
Following IV administration, the total body
clearance (Cltot) was 321.70 ml/kg.h, the volume of
distribution at steady-state (Vdss) was 13.26 L/kg
and the value of the elimination half-life (t1/2β)
was 29.29 h. After SC administration, the
elimination half-life (t1/2el), mean residence time
(MRT) and maximum plasma concentration (Cmax) were
significantly higher (36.22 h, 52.54 h and 882.19 ng/ml)
than after IM route (31.69 h, 45.89 h and 714.72 ng/ml),
respectively. Tulathromycin was bound to the extent
of 36% to plasma protein of healthy rabbits. The
absolute bioavailabilities were 88.07 and 94.25%
after IM and SC injections.
Conclusion: Thus
a single dose of tulathromycin is promising
treatment for most respiratory disease in rabbits.
Keywords: Pharmacokinetics, tulathromycin,
bioavailability, rabbits.
