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Open Access
Copyright: The authors. This article is an open access
article licensed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/2.0) which permits unrestricted use,
distribution and reproduction in any medium, provided the work is properly
cited.
Original Research
1.
Lipofundin 20% induces
hyperlipidemia and oxidative stress in male
sprague dawley rats -
L
DelgadoRoche, Á FragaPerez, M A BequerViart and Y
Hernandez-Matos
Vet World. 2012; 5(3): 133-137
doi:
10.5455/vetworld.201 2.133-137.
Abstract
Lipofundin is a lipid emulsion used in parenteral
nutrition. One of adverse effects reported for
this kind of pharmaceutical products is the
capacity to induce oxidative stress, which is an
important contributor of many diseases, such as
cardiovascular diseases. The aim of the present
work was to evaluate the effects of Lipofundin
administration on lipid profile and serum redox
biomarkers, in order to determine if both events
are responsible for the undesirable effects of
this lipid emulsion. Male Sprague Dawley rats were
intravenously administered with 2 mL/kg of
Lipofundin 20% daily, for 8 days. Then, serum
lipid profile and redox biomarkers were
spectrophotometrically determined. A significant
increase (p<0,05) of serum lipids and biomolecules
damages was observed at the end of the experiment,
while a reduction of antioxidant capacity was also
detected in treated rats compared with controls.
Our data demonstrated that Lipofundin 20% induces
hyperlipidemia, which promotes an oxidative stress
state in Sprague Dawley rats.
Keywords:
Lipofundin 20%, hyperlipidemia, oxidative stress,
parenteral nutrition.
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