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Open Access
Copyright: The authors. This article is an open access
article licensed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/2.0) which permits unrestricted use,
distribution and reproduction in any medium, provided the work is properly
cited.
Original Research
3.
Preparation and evaluation of veterinary 0.1%
injectable solution of atropine sulphate -
F K Mohammad, F T Abachi, A S Alias, M Y Al-Attar,
T A Al-Sawah and T A Al-Talib
Vet World. 2012; 5(3): 145-149
doi:
10.5455/vetworld.201 2.145-149
Abstract
This study introduces the know-how of preparing a
multiple injection form atropine sulphate
solution. An injectable aqueous solution of
atropine sulphate at a concentration of 0.1%. was
prepared under aseptic conditions in dark glass
bottles each containing 50 ml. The preparation was
intended for animal use only. It contained 1g
atropine sulphate, 9 g sodium chloride as a normal
saline, benzyl alcohol 15 ml as a preservative and
water for injection up to 1000 ml. The pH of the
solution was adjusted to 4.2 (range 3.0-6.5). The
preparation of 0.1% atropine sulphate solution was
clear colorless solution free from undesired
particles. It complied with the requirements for
injectable solutions. Further, the preparation was
safe when used under laboratory conditions in
chicks, rats and donkeys. It was also effective in
preventing dichlorvos (an organophosphate
insecticide)-induced poisoning in chicks in a
manner comparable to a commercial preparation of
0.1% atropine sulphate. In conclusion, the
know-how of a preparation of 0.1% atropine
sulphate solution is presented for veterinary use.
Keywords: Atropine sulphate, Injectable
formulation, Organophosphate.
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