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Original Research
6.
Haemato-biochemical studies on triflupromazine HCL
and diazepam premedication for propofol anaesthesia
in dogs -
L. Suresha , B.N. Ranganath, M.S.Vasanth ,
L.Ranganath
Vet World. 2012; 5(11): 672-675
doi:
10.5455/vetworld.2012.
672-675
Abstract
Aim:
To study the effect of Triflupromazine Hcl and
diazepam in combination with propofol as
preanaesthetic on haemato-biochemical parameters in
dogs was carried out.
Materials and Methods:
16 clinical cases of dogs undergoing different
surgical interventions irrespective of age, sex and
breed were allotted randomly in to two groups viz.,
Group A (Triflupromazine Hcl – propofol) and Group B
(diazepam – propofol) consisting eight dogs each.
Blood samples were collected at different intervals
from both the Groups in heparinised syringes as
follows: Prior to premedication, fifteen minutes
after premedication, fifteen minutes, one hour, six
hour, 24 hour and 48 hour after induction with
Propofol. The samples were subjected for various
hematological and biochemical analysis.
Results:
Hematology revealed a significant (P 0.05) fall in
total erythrocyte count (TEC), packed cell volume (PCV)
and haemoglobin (Hb), whereas TLC showed a non
significant decrease in both the groups throughout
the observation period of 48 hours. In the present
study blood glucose level was significantly
increased between 15 min to one hour in Group A and
15 min to 6 hours of observation period of the study
in Group B. The total plasma protein (TPP), alanine
amino transferase (ALT),alkaline phosphatase (AP)
and creatinine levels did not differ significantly
in both the groups throughout the observation period
of 48 hours.
Conclusion: Both the anaesthetic
combinations were found to be safe and effective
with smooth and stress free recovery. However
triflupromazine Hcl premedication proved to be
better with quick sedative effect, long duration of
anaesthesia with less induction dose of propofol and
shorter recovery time than diazepam.
Key words:
dogs, diazepam, haemato-biochemical, propofol,
triflupromazine
