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Original Research
10.
Single intramuscular dose toxicokinetics of
manganese in broiler chicks -
Muna Al-Zubaidy, Fouad Kasim Mohammad
Vet World. 2012; 5(9): 560-564
doi:
10.5455/vetworld.2012.5
60-564
Abstract
Aim:
Manganese (Mn) produces neurobehavioral toxicity in
various animal species including the young chicks.
The present study examines toxicokinetics of Mn in
7-10-day old chicks after an intramuscular injection
at 20 mg/kg.
Materials and Methods: Samples
of the blood, whole brain, liver and kidney were
obtained from chicks (5/each time period) at 0 time
(base-line) and then at times between 0.17 to 4 h.
The concentrations of Mn in the plasma and tissues
were determined by atomic absorption spectrometry.
Toxicokinetic parameters of Mn were calculated from
the mean metal concentrations in the plasma by a
non-compartmental analysis using a Windows-based
computer program.
Results: Injection of Mn
significantly increased the metal levels in the
plasma, whole brain, liver and kidney of the chicks
when compared to respective base-line control values
at times 0.17 to 4 h after the injection (with the
exception at 2 and 4 h in the brain). The highest
concentration of Mn in the plasma and the whole
brain appeared one h after the injection, whereas
those of the liver and kidney appeared 4 h
post-injection. The concentrations of Mn in the
plasma ranged between 0.43 to 1.2 µg/ml within 0.17
to 4 h. Those of the whole brain, liver and kidney
were 0.11– 0.46, 6.3–15 and 5.3–22.9 µg/g,
respectively. The elimination half-life of Mn was
3.02 h with steady state volume of distribution
24.34 L/kg and total body clearances of 4.78 L/h/kg.
The mean residence time of Mn was 5.09 h and its
area under the plasma concentration-time curve (0- )
was 4.18 μg.h/ml. The elimination half-life of Mn
from the brain was 3.12 h with an elimination rate
constant of 0.22 h-1. Conclusion: The data
suggest that Mn is well absorbed and rapidly
distributed after an intramuscular administration in
chicks and further support the reported
neurobehavioral toxic effects of the metal which are
observed within one h after treatment.
Keywords:
Chick, Half-life, Manganese, Neurotoxicity,
Toxicokinetics.
