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Open Access
Copyright: The authors. This article is an open access
article licensed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/2.0) which permits unrestricted use,
distribution and reproduction in any medium, provided the work is properly
cited.
Review Article
(Published online : 14-01-2013)
13.
DNA vaccine: the miniature miracle -
Karthik
Kumaragurubaran and Karthik Kaliaperumal
Vet World. 2013; 6(4): 228-232
doi:
10.5455/vetworld.2013. 228-232
Abstract
DNA, the essential part of the life is making way in to new vaccine technology.
Plasmid vectors from the bacteria have revolutionized the world of vaccine
design by its new technology – DNA vaccines. Small portion of the nucleotides
from the pathogen held under the control of promoter in a plasmid vector can be
used as a vaccine. DNA vaccines alleviate the odds of the other vaccines by
having good hold on both the faces of the immunity. The key to the success of
DNA vaccine lies in the route of administration of the vaccine which can be done
in many ways. Prime boost strategy is an approach used to boost the action of
DNA vaccine. To date there are only four DNA vaccine available in the market.
Keywords: DNA vaccine, plasmid vector, prime boost approach, transgene
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