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Research
10. Haematological and
hypoglycemic potential Anethum graveolens seeds extract in normal and diabetic
Swiss albino mice - Nidhi Mishra
Vet World. 2013; 6(8):
502-507
doi:
10.5455/vetworld.2013.502-507
Abstract
Aim: The present study
investigates the hypoglycemic and hematopoetic potential of the
seed extracts of Anethum graveolens.
Context: A. graveolens (Apiaceae) is an Indian traditional
herb. Leaves and seeds of this plant are known for their medicinal
properties. Leaves are best used in fresh form while seeds are
used in dried form.
Materials and Methods: Control and alloxan-induced diabetic
mice were orally treated once in a day with aqueous and ethanol
extracts for the period of 15 days and the effect of both extracts
on body weight, organ weight and blood glucose level were
determined. For the hematological study, aqueous (3.04 g/kg),
ethanol extracts (6.98 g/kg) and carvone (100 mg/kg body weight)
were orally administered once in a day to male Swiss albino mice.
While control mice were supplemented with normal saline.
Results: A significant decrease (P<0.05) in blood glucose
level after administration of aqueous extract was observed along
with a significant increase in body and organ weight in alloxan
induced diabetic mice after the treatment with plant extracts.
Moreover carvone and the aqueous extract significantly increased
(P<0.05) red blood cell count (11.94 and 10.42%), hemoglobin
(15.55 and 15.06%), Mean Corpuscular Haemogolobin (MCH) (2.80 and
4.80%), Mean Corpuscular Haemoglobin Content (MCHC) (8.16 and
9.57%) when compared with control. While in ethanol extract no
such changes were observed except in WBC, which was increased by
9.43%.
Conclusion: The result suggests an anti-diabetic property
of the aqueous and ethanol extracts. Both extract and carvone also
have beneficial effect on hematological parameters.
Keywords: aqueous extract, blood glucose level, ethanol
extract
