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Research
(Published
online : 23-05-2013)
13. Pharmacokinetic studies of meloxicam after
its intravenous administration in local goat (Capra hircus) of Assam -
Abdul Rakeeb Wani, Rohini K. Roy, Ajmal Ashraf and Dulal C. Roy
Vet World. 2013; 6(8): 516-520
doi:
10.5455/vetworld.2013.516-520
Abstract
Aim: The aim of the present
study was to determine the meloxicam concentrations in the plasma of goats at
different time intervals after its administration by IV route and data were
used to determine the different pharmacokinetic parameters and the
bioavailability of meloxicam in goats.
Materials and Methods: The
present study was conducted on 12 to 18 months old, five adult male local
goats (Capra hircus) of Assam, with body weight ranging between 10 to 18 kg.
All goats were clinically sound and healthy and reared at Goat Research
station, Burnihat, Assam. A single dose of meloxicam was administered
intravenously into the jugular vein of goats at the rate of 1 mg/kg body
weight. Blood samples were analyzed with the help of high performance liquid
chromatography (HPLC) system.
Results: After single intravenous
administration of meloxicam at the dose rate of 1mg/kg, the mean peak plasma
level of the drug was 6.538±0.1189 µg/ml at 2 min. The mean elimination half
life (t1/2β) and mean distribution half life (t1/2α) were 484.5±85.1202 min
and 28.68±1.4206 min respectively. The mean values of AUC and AUMC were
2635.272±94.2389 µg.min/ml and 1620332±92456.46 µg.min2/ml respectively. The
mean values of volume of distribution (Vd) and mean residence time (MRT) were
0.276±0.0103 L/kg and 612.948±14.5771 min respectively.
Conclusion:
After calculating various pharmacokinetic determinants, dosage regimens were
computed for meloxicam in goats, based on minimum effective therapeutic plasma
concentration of 0.7 µg/ml.To maintain the minimum effective concentration of
0.7 µg/ml in plasma for 25 hours following iv administration of meloxicam, an
initial loading dose of 1.1 mg/kg body weight followed by a maintenance dose
of 1mg/kg body weight/day is recommended.
Keywords: goat,
meloxicam, pharmacokinetic parameters
