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Open Access
Copyright: The authors. This article is an open access
article licensed under the terms of the Creative Commons Attribution License
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distribution and reproduction in any medium, provided the work is properly
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Review (Published
online : 20-09-2013)
1. Genetics of ovulation rate in farm animals
- R. Kumar Pramod, Sanjeev Kumar Sharma, Rohit Kumar and Anju Rajan
Veterinary World, 6(11): 833-838
doi:
10.14202/vetworld.2013.833-838
Abstract
Rate of ovulation (i.e. fecundity)
is largely influenced by both genetic and environmental factors.
The ovarian growth factors including members of bone morphogenetic
proteins (BMPs) play a central role in determining ovulation quota
and litter size. Naturally occurring mutation in sheep and
knock-out and knock–down studies in murine indicated the
importance of bone morphogenetic protein 15 (BMP15), growth
differentiation factor 9 (GDF9) and bone morphogenetic protein
receptor 1B (BMPR1B) genes in mammals. These factors have major
regulatory roles during the gonadotrophin-independent and
-dependent stages of follicle development. Understanding of BMPs
in reproduction assists in the treatment of infertility/ sterility
in animals.
Keywords: bone morphogenetic proteins, follicle stimulating
hormone, growth differentiation factor, knock-out, mutation.
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