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Open Access
Copyright: The authors. This article is an open access
article licensed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/2.0) which permits unrestricted use,
distribution and reproduction in any medium, provided the work is properly
cited.
Review (Published
online : 18-10-2013)
14. Overview of Johne's disease immunology -
Ashutosh Wadhwa, Naveen Kumar, Andres Velasco-Villa and Shigetoshi Eda
Veterinary World, 6(11): 901-904
doi:
10.14202/vetworld.2013.901-904
Abstract
Johne's disease or paratuberculosis
is one of the most economically important diseases of the
livestock. Most of the economic losses associated with
paratuberculosis are related to decreased milk production, reduced
fertility and higher rates of culling. Understanding the
immunology of the disease is very important for better
understanding of the interplay between the host and the causative
agent, Mycobacterium avium subsp. paratuberculosis (MAP). After
uptake of MAP by macrophages residing in host's intestinal tissue,
two possible scenarios may emerge; MAP may be destroyed or may
establish persistent infection within the macrophages. If MAP
persists in the infected macrophage, it continuously modulates
adaptive immune responses of the animal. In this short review we
describe the host-pathogen interactions in Johne's disease and
highlights potential protective mechanisms in order for future
design of more effective diagnostic method and vaccine.
Keywords: immunology, Johne's disease, paratuberculosis.
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