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Open Access
Copyright: The authors. This article is an open access
article licensed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/2.0) which permits unrestricted use,
distribution and reproduction in any medium, provided the work is properly
cited.
Review (Published
online : 21-10-2013)
15. Candidate gene markers for sperm quality and
fertility in bulls - Chinmoy Mishra, Tapan Kumar Palai, Laxmi Narayan
Sarangi, Bikash Ranjan Prusty and Biswa Ranjan Maharana
Veterinary World, 6(11): 905-910
doi:
10.14202/vetworld.2013.905-910
Abstract
Fertility is one of the primary
traits of reproduction in bulls. Decrease in fertility is a
multifactorial condition and is very difficult to diagnose. Among
various causes, genetic abnormality holds a major share. By
identifying various genes that have effects on fertility, the
genetic cause behind subferility can be explored and also other
non genetic factors can be identified. Advancement of molecular
genetic tools now easily enables us to explore individual genes in
animals. Identification of these genes will eventually lead to
genome assembly and development of novel tools for analysing
complex genetic traits. This paper gives a brief idea about the
candidate genes for bull fertility, including genes encoding
hormones and their receptors, proteins of the seminal plasma,
proteins involved in spermatozoa-ovum binding and genes
influencing sexual development. The chromosomal location and gene
structure are described, based on the bovine genome assembly.
Keywords: bull, fertility, gene, sperm.
References
|
1. Winaya, A., Rahayu, I.D., Amin, M. and Herliantin. (2012)
The genetic variation of Bali cattle (Bos javanicus) based on
sex related Y chromosome gene. Animal Production 13 (3):
150-155. |
|
|
2. Mukherjee, A., Dass, G., Mohanarao, G.J., Gohain, M.,
Brahma, B., Datta, T.K. and De, S. (2013) Absolute copy number
differences of Y chromosomal genes between crossbred (Bos
taurus x Bos indicus) and Indicine bulls. Journal of Animal
Science and Biotechnology 4(1):15.
http://dx.doi.org/10.1186/2049-1891-4-15
PMid:23556478 PMCid:PMC3668231 |
|
|
3. Angelopoulou, R., Lavranos, G. and Manolakou, P. (2012) Sex
determination strategies in 2012: towards a common regulatory
model? Reproductive Biology and Endocrinology 10: 13.
http://dx.doi.org/10.1186/1477-7827-10-13
PMid:22357269 PMCid:PMC3311596 |
|
|
|
4. Wang, R.S., Yeh, S., Tzeng, C.R. and Chang, C. (2003)
Androgen receptor roles in spermatogenesis and fertility:
lessons from testicular cell specific androgen receptor knock
out mice 30(2):119-132. |
|
|
|
5. Li-hong, Q., Ying, R., Chang, L., Jin-yu, Z., Jia-bao, Z.
and Zhi-hui Z. (2010) SNP Analysis of 5'UTR of androgen
receptor gene and its relationship with semen quality in
bulls. Journal of Jilin Agricultutal University 32 (3):
335-339. |
|
|
6. Saunders, P.T., Sharpe, R.M., Williams, K., Macpherson, S.,
Urquart, H., Irvine, D. S., Millar, M.R. (2001) Differential
expression of oestrogen receptor alpha and beta proteins in
the testes and male reproductive system of human and non-
human primates. Molecular Human Reproduction 7: 227- 236.
http://dx.doi.org/10.1093/molehr/7.3.227
PMid:11228242 |
|
|
7. Ebling, D.W., Ruffer, J., Whittington, R., Vanarsdalen, K.,
Broderick, G.A., Malkowicz, S.B., Wein, A.J. (1997)
Development of prostate cancer after pituitary dysfunction: a
report of 8 patients. Urology 49(4): 564-568.
http://dx.doi.org/10.1016/S0090-4295(96)00541-9 |
|
|
8. Stormshak, F. and Bishop, C.V. (2008) Estrogen and
progesterone signaling: Genomic and nongenomic actions in
domestic ruminants. Journal of Animal Science 86:299-315.
http://dx.doi.org/10.2527/jas.2007-0489
PMid:17965328 |
|
|
9. Miah, A.G., Salma, U., Sinha, P.B., Hölker, M., Tesfaye,
D., Cinar, M.U., Tsujii, H. and Schellander, K. (2011)
Intracellular signaling cascades induced by relaxin in the
stimulation of capacitation and acrosome reaction in fresh and
frozen- thawed bovine spermatozoa. Animal Reproduction Science
125(1-4): 30-41.
http://dx.doi.org/10.1016/j.anireprosci.2011.03.010
PMid:21493019 |
|
|
10. Ferlin, A., Pepe, A., Gianesello, L., Garolla, A., Feng,
S., Facciolli, A., Morello, R., Agoulnik, A.I. and Foresta, C.
(2009) New roles for INSL3 in adults. Annals of New York
Academy of Sciences 1160: 215-218.
http://dx.doi.org/10.1111/j.1749-6632.2008.03787.x
PMid:19416191 |
|
|
11. Nilsson, B., Rosen, S.W., Weintraub, B.D. and Zopf, D.A.
(1986) Differences in the carbohydrate moieties of the common
alpha-subunits of human chorionic gonadotropin, luteinizing
hormone, follicle-stimulating hormone, and thyrotropin:
preliminary structural inferences from direct methylation
analysis. Endocrinology 119(6):2737-2743.
http://dx.doi.org/10.1210/endo-119-6-2737
PMid:3096695 |
|
|
12. Bernard, D.J., Fortin, J., Wang, Y. and Lamba, P. (2010).
Mechanisms of FSH synthesis: what we know, what we don't, and
why you should care. Fertility and Sterility 93(8): 2465-2485.
http://dx.doi.org/10.1016/j.fertnstert.2010.03.034
PMid:20403589 |
|
|
13. Dai, L.S., Zhao, Y.M., Zhang, G.L., Zhao, R.F., Jiang, H.,
Ma, T.H., Gao, Y., Yuan, B., Xu, Y.L., Yu, W.Y., Zhao, Z.H.
and Zhang, J.B. (2011) Molecular cloning and sequence analysis
of follicle-stimulating hormone beta polypeptide precursor
cDNA from the bovine pituitary gland. Genetics and Molecular
Research 10(3): 1504-1513.
http://dx.doi.org/10.4238/vol10-3gmr997
PMid:21823101 |
|
|
14. Dai, L.S., Zhao, Z.H., Zhao, R.F., Xiao, S., Jiang, H.,
Yue, X., Li, X., Gao, Y., Liu, J. and Zhang, J. (2009) Effects
of novel single nucleotide polymorphisms of the FSH
beta-subunit gene on semen quality and fertility in bulls.
Animal Reproduction Science 114: 14-22.
http://dx.doi.org/10.1016/j.anireprosci.2008.08.021
PMid:18829190 |
|
|
15. Lirón, J.P., Prando, A.J., Fernández, M.E., Ripoli, M.V.,
Rogberg-Mu-oz, A., Goszczynski, D.E., Posik, D.M., Peral-
García, P., Baldo, A. and Giovambattista, G. (2012)
Association between GNRHR, LHR and IGF1 polymor- phisms and
timing of puberty in male Angus cattle. BMC Genetics13:26.
http://dx.doi.org/10.1186/1471-2156-13-26
PMid:22480211 PMCid:PMC3344682 |
|
|
16. Yang, W.C., Tang, K.Q., Yu, J.N., Zhang, C.Y., Zhang, X.X.
and Yang, L.G. (2011) Effects of MboII and BspMI polymorphisms
in the gonadotropin releasing hormone receptor (GnRHR) gene on
sperm quality in Holstein bulls. Molecular Biology Reports
38(5): 3411-3415.
http://dx.doi.org/10.1007/s11033-010-0450-2
PMid:21104139 |
|
|
17. Sang, L., Du, Q.Z., Yang, W.C., Tang, K.Q., Yu, J.N., Hua,
G., Zhang, X.X., Yang, L.G. (2011) Polymorphisms in follicle
stimulation hormone receptor, inhibin alpha, inhibin bata A,
and prolactin genes, and their association with sperm quality
in Chinese Holstein bulls. Animal Reproduction Science
126:151-156.
http://dx.doi.org/10.1016/j.anireprosci.2011.04.023
PMid:21684095 |
|
|
18. Toulis, K.A., Iliadou, P.K., Venetis, C.A., Tsametis, C.,
Tarlatzis, B.C., Papadimas, I. and Goulis, D.G. (2010) Inhibin
B and anti-Mullerian hormone as markers of persistent
spermatogenesis in men with non-obstructive azoospermia: a
meta-analysis of diagnostic accuracy studies. Human
Reproduction Update 16 (6): 713-724.
http://dx.doi.org/10.1093/humupd/dmq024
PMid:20601364 |
|
|
19. Bhardwaj, A., Nayan, V., Parvati, Mamta and Gupta, A.K.
(2012) Inhibin: A role for fecundity augmentation in farm
animals. Asian Journal of Animal and Veterinary Advances 7:
771-789.
http://dx.doi.org/10.3923/ajava.2012.771.789 |
|
|
20. Sang, L., Du, Q.Z., Yang, W.C., Tang, K.Q., Yu, J.N., Hua,
G.H., Zhang, X.X. and Yang, L.G. (2011) Polymorphisms in
follicle stimulation hormone receptor, inhibin alpha, inhibin
bata A, and prolactin genes, and their association with sperm
quality in Chinese Holstein bulls. Animal Reproduction Science
126 (3-4):151-156.
http://dx.doi.org/10.1016/j.anireprosci.2011.04.023
PMid:21684095 |
|
|
21. Arias, J.A., Keehan, M., Fisher, P., Coppieters, W. and
Spelman, R. (2009) A high density linkage map of the bovine
genome. BMC Genetics 10:18.
http://dx.doi.org/10.1186/1471-2156-10-18
PMid:19393043 PMCid:PMC2680908 |
|
|
22. Camper, S.A., Luck, D.N., Yao, Y., Woychik, R.P., Goodwin,
R.G., Lyons, R.H. and Rottman, F.M. (1984) Charac- terization
of the bovine prolactin gene. DNA 3: 237-249.
http://dx.doi.org/10.1089/dna.1.1984.3.237
PMid:6086257 |
|
|
|
23. Wallis, M. (1974) The primary structure of bovine
prolactin. Federation of the Societies of Biochemistry and
Molecular Biology 44: 205-208. |
|
|
24. Hayes, H., Le Chalony, C., Goubin, G., Mercier, D., Payen,
E.J., Bignon, C. and Kohno, K. (1996) Localization of ZNF164,
ZNF146, GGTA1, SOX2, PRLR and EEF2 on homeologous cattle,
sheep, and goat chromosomes by fluorescent in situ
hybridization and comparison with human gene map. Cytogenetics
and Cell Genetics 72: 342-346.
http://dx.doi.org/10.1159/000134218
PMid:8641144 |
|
|
25. Bole-Feysot, C.H., Goffin, V., Edery, M., Binart, N. and
Kelly, P.A. (1998) Prolactin (PRL) and its receptor: actions,
signal transduction pathways and phenotypes observed in PRL
receptor knockout mice. Endocrine Reviews 19: 225- 268.
http://dx.doi.org/10.1210/er.19.3.225
PMid:9626554 |
|
|
26. Henderson, H.L., Hodson, D.J., Gregory, S.J., Townsend, J.
and Tortonese, D.J. (2008) Gonadotropin-releasing hormone
stimulates prolactin release from lactotrophsin photoperiodic
species through a gonadotropin-independent mechanism. Biology
of Reproduction 78: 370-377.
http://dx.doi.org/10.1095/biolreprod.107.064063
PMid:18094358 |
|
|
27. Seidah, N.G., Manjunath, P., Rochemont, J., Sairam, M.R.
and Chre’tien, M. (1987) Complete amino acid sequence of
BSP-A3 from bovine seminal plasma (homology to PDC- 109 and to
the collagen-binding domain of fibronectin. Biochemistry
Journal 243: 195-203.
PMid:3606570 PMCid:PMC1147832 |
|
|
28. Manjunath, P., Lefebvre, J., Jois, P.S., Fan, J. and
Wright, M.W. (2009) New nomenclature for mammalian BSP genes.
Biology of Reproduction 80: 394-397.
http://dx.doi.org/10.1095/biolreprod.108.074088
PMid:18923155 PMCid:PMC2844493 |
|
|
29. Gwathmey, T.M., Ignotz, G.G., Mueller, J.L., Manjunath, P.
and Suarez, S.S. (2006). Bovine seminal plasma proteins
PDC-109, BSP-A3, and BSP-30-kDa share functional roles in
storing sperm in the oviduct. Biology of Reproduction 75(4):
501-507.
http://dx.doi.org/10.1095/biolreprod.106.053306
PMid:16790686 |
|
|
|
30. Kumar, P., Kumar, D., Singh, I. and Yadav, P.S. (2012)
Seminal Plasma Proteome: Promising Biomarkers for Bull
Fertility. Agricultural research 1(1): 78-86. |
|
|
31. D'Amours, O., Bordeleau, L., Frenette, G., Leclerc, P.,
Blondin, P. and Sullivan, R. (2012) Binder of sperm 1 (BSP1)
and epididymal sperm binding protein 1 (ELSPBP1) are
associated with different bull sperm subpopulations.
Reproduction 143(6): 759-771.
http://dx.doi.org/10.1530/REP-11-0392
PMid:22457431 |
|
|
32. Srivastava, P.N., Arbtan, K., Takei, G.H., Huang, T.F.,
Yanagimachi, R. (1986) a-L-fucosidase from bull seminal
plasma: Its purification and acrosome reaction promoting
property. Biochemical and Biophysical Research Communi-
cations 137(3): 1061-1068.
http://dx.doi.org/10.1016/0006-291X(86)90333-5 |
|
|
33. Cancel, A.M., Chapman, D.A. and Killian, G.J. (1997)
Osteopontin is the 55-kilodalton fertility-associated protein
in Holstein bull seminal plasma. Biology of Reproduction.
57(6):1293-1301.
http://dx.doi.org/10.1095/biolreprod57.6.1293
PMid:9408233 |
|
|
34. Sato, H., Taketomi, Y., Isogai, Y., Miki, Y., Yamamoto,
K., Masuda, S., Hosono, T., Arata, S., Ishikawa, Y., Ishii,
T., Kobayashi, T., Nakanishi, H., Ikeda, K., Taguchi, R.,
Hara, S., Kudo, I. and Murakami, M. (2010) Group III secreted
phospholipase A2 regulates epididymal sperm maturation and
fertility in mice. Journal of Clinical Investigation 120:
1400–1414.
http://dx.doi.org/10.1172/JCI40493
PMid:20424323 PMCid:PMC2860917 |
|
|
35. Gerena, R.L., Irikura, D., Eguchi, N., Urade, Y. and
Killian, G.J. (2000) Immunocytochemical localization of
lipocalin- type prostaglandin D synthase in bull testis and
epididymis and on ejaculated sperm. Biology of Reproduction
62(3): 547-556.
http://dx.doi.org/10.1095/biolreprod62.3.547
PMid:10684794 |
|
|
36. Koubova, J., Menke, D.B., Zhou, Q., Capel, B., Griswold,
M.D. and Page, D.C. (2006) Retinoic acid regulates sex-
specific timing of meiotic initiation in mice. Proceedings of
the National Academy of Sciences of the United States of
America 103: 2474-2479.
http://dx.doi.org/10.1073/pnas.0510813103
PMid:16461896 PMCid:PMC1413806 |
|
|
37. Moura, A.A., Koc, H., Chapman, D.A. and Killian, G.A.,
(2006) Identi?cation of proteins in the accessory sex gland ?uid
associated with fertility indexes of dairy bulls: a proteomic
approach. Journal of Andrology 27: 201-211.
http://dx.doi.org/10.2164/jandrol.05089
PMid:16278371 |
|
|
38. Sutovsky, P., Terada, Y. and Schatten, G. (2001) Ubiquitin-
based sperm assay for the diagnosis of male factor
infertility. Human Reproduction 16: 250-258.
http://dx.doi.org/10.1093/humrep/16.2.250
PMid:11157815 |
|
|
39. Jones, K.T. (1998) Ca2+ oscillations in the activation of
the egg and development of the embryo in mammals.
International Journal of Developmental Biology 42(1): 1-10.
PMid:9496781 |
|
|
40. Malcuit, C., Knott, J.G., He, C., Wainwright, T., Parys,
J.B., Robl, J.M., Fissore, R.A. (2005) Fertilization and
inositol 1,4,5-trisphosphate (IP3)-induced calcium release in
type-1 inositol 1,4,5-trisphosphate receptor down-regulated
bovine eggs. Biology of Reproduction 73(1): 2-13.
http://dx.doi.org/10.1095/biolreprod.104.037333
PMid:15744020 |
|
|
41. Pan, Q., Ju, Z., Huang, J., Zhang, Y., Qi, C., Gao, Q.,
Zhou, L., Li, Q., Wang, L., Zhong, J., Liu, M. and Wang, C.
(2013) PLCz functional haplotypes modulating promoter
transcriptional activity are associated with semen quality
traits in Chinese Holstein bulls. PLoS ONE 8(3): e58795.
http://dx.doi.org/10.1371/journal.pone.0058795
PMid:23554927 PMCid:PMC3598912 |
|
|
42. Tardif, S., Wilson, M.D., Wagner, R., Hunt, P.,
Gertsenstein, M., Nagy, A., Lobe, C., Koop, B.F. and Hardy,
D.M. (2010) Zonadhesin is essential for species specificity of
sperm adhesion to the egg zona pellucida. Journal of
Biological Chemistry 285: 24863-24870.
http://dx.doi.org/10.1074/jbc.M110.123125
PMid:20529856 PMCid:PMC2915722 |
|
|
43. Ikawa, M., Nakanishi, T., Yamada, S., Wada, I., Kominami,
K., Tanaka, H., Nozaki, M., Nishimune, Y. and Okabe, M. (2001)
Calmegin is required for fertilin a/ß heterodimerization and
sperm fertility. Developmental Biology 240: 254-261.
http://dx.doi.org/10.1006/dbio.2001.0462
PMid:11784061 |
|
|
44. Evans, J.P., Kopf, G.S. and Schultz, R.M. (1997)
Characterization of the binding of recombinant mouse sperm
fertilin beta subunit to mouse eggs: evidence for adhesive
activity via an egg beta 1 integrin-mediated interaction.
Developmental Biology 187(1): 79-93.
http://dx.doi.org/10.1006/dbio.1997.8611
PMid:9224676 |
|
|
45. Arcelay, E., Salicioni, A.M., Wertheimer, E. and Visconti.
P.E. (2008) Identification of proteins undergoing tyrosine
phosphorylation during mouse sperm capacitation. International
Journal of Developmental Biology 52: 463- 472.
http://dx.doi.org/10.1387/ijdb.072555ea
PMid:18649259 |
|
|
46. Gross, M.K., Toscano, D.G. and Toscano, W.A.J.R. (1987)
Calmodulin-mediated adenylate cyclase from mammalian sperm.
Journal of Biological Chemistry 262: 8672-8676.
PMid:3597392 |
|
|
47. Vijayaraghavan, S., Kevin D. Trautman, Said A. Goueli, and
Daniel W. Carr (1997) A tyrosine-phosphorylated 55- kilodalton
motility ssociated bovine sperm protein is regulated by cyclic
adenosine 3',5'-monophosphates and calcium. Biology of
Reproduction 56: 1450-1457.
http://dx.doi.org/10.1095/biolreprod56.6.1450
PMid:9166697 |
|
|
48. Odet, F., Gabel, S., London, R.E., Goldberg, E. and Eddy,
E.M. (2013) Glycolysis and mitochondrial respiration in mouse
LDHC-null sperm. Biology of Reproduction 88(4): 95-95.
http://dx.doi.org/10.1095/biolreprod.113.108530
PMid:23486916 |
|
|
49. Langford, K.G., Zhou, Y., Russell, L.D., Wilcox, JN., and
Bernstein, K. E. (1993) Regulated expression of testis
angiotensin-converting enzyme during spermatogenesis in mice.
Biology of Reproduction 48: 1210-1218.
http://dx.doi.org/10.1095/biolreprod48.6.1210
PMid:8391328 |
|
|
50. Howard, T.E., Shai, S.Y., Langford, K.G., Martin, B.M.,
and Bernstein, K.E. (1990) Transcription of testicular
angiotensin converting enzyme (ACE) is initiated within the
12th intron of the somatic ACE gene. Molecular and Cell
Biology 10: 4294-4302.
PMid:2164636 PMCid:PMC360974 |
|
|
51. Bernstein, K.E., Ong, F.S., Blackwell, W.B., Shah, K.H.,
Giani, J.F., Gonzalez-Villalobos, R.A., Shen, X.Z. and Fuchs,
S. (2013) A modern understanding of the traditional and
nontraditional biological functions of angiotensin- converting
enzyme. Pharmacological Reviews 65(1):1-46.
http://dx.doi.org/10.1124/pr.112.006809
PMid:23257181 |
|
|
52. Vogel, T., Dechend, F., Manz, E., Jung, C., Jakubiczka,
S., Fehr, S., Schmidtke, J. and Schnieders, F., (1997)
Organization and expression of bovine TSPY. Mammalian Genome
8(7): 491-496.
http://dx.doi.org/10.1007/s003359900482
PMid:9195993 |
|
|
53. Bonfiglio, S., De Gaetano A., Tesfaye, K., Grugni, V.,
Semino, O. and Ferretti, L. (2012) A novel USP9Y polymorphism
allowing a rapid and unambiguous classification of Bos taurus
Y chromosomes into haplogroups. Animal Genetics 43(5):
611-613.
http://dx.doi.org/10.1111/j.1365-2052.2012.02328.x
PMid:22497446 |
|
|
54. Luddi, A., Margollicci, M., Gambera, L., Serafini, F.,
Cioni, M., De Leo, V., Balestri, P. and Piomboni, P. (2009)
Spermatogenesis in a man with complete deletion of USP9Y. New
England Journal of Medicine 60: 881-885.
http://dx.doi.org/10.1056/NEJMoa0806218
PMid:19246359 |
|
|
