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Veterinary World
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ISSN (Online):
2231-0916 |
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Open Access
Copyright: The authors. This article is an open access
article licensed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/2.0) which permits unrestricted use,
distribution and reproduction in any medium, provided the work is properly
cited.
Review
(Published
online : 04-07-2013)
10.
Does contemporary canine diet cause cancer? ; A review -
Joseph B Gentzel
Vet World. 2013; 6(9):
632-639
doi:
10.14202/vetworld.2013.632-639
Abstract
Recent discoveries have discerned
the presence of advanced glycation end products (AGEs) and their
impact on chronic diseases that include cancer in dogs. AGEs are
closely allied with chronic systemic inflammation (metaflammation).
These two occurrences are observed in many cancers in both humans
and dogs. AGEs are exogenous and endogenous. Exogenous AGEs occur
from, among other causes, ingestion of food that is affected by
the Maillard reaction in its preparation. The result is an
accumulation of AGEs and progressive metaflammation that is linked
with many cancers in both humans and dogs. Aspects of AGE
ingestion and formation are reviewed in association with the
contemporary canine diet that is primarily a kibbled meal based
diet. A novel canine diet paradigm is offered as one that
diminishes the AGE/ metaflammation axis. This is proposed to be
less carcinogenic than the current canine diet in use by much of
the civilized world. The proposed paradigm is a unique approach
that offers opportunities to be tested for AGE and metaflammation
accumulation that results in diminished prevalence and incidence
of cancer in dogs. The paradigm diet is suggested as a prevention,
treatment, and recovery aide from cancer.
Keywords: advanced glycation end products, cancer, canine
diet, dogs, inflammation, maillard reaction
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