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Open Access
Copyright: The authors. This article is an open access
article licensed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/2.0) which permits unrestricted use,
distribution and reproduction in any medium, provided the work is properly
cited.
Research
(Published
online : 28-07-2013)
22.
Protective role of Nigella sativa against
experimentally induced type-II diabetic nuclear damage in Wistar rats -
T. J. Sheikh,
D. V. Joshi, B. J. Patel and C. M. Modi
Vet World. 2013; 6(9): 698-702
doi:
10.14202/vetworld.2013.698-702
Abstract
Aim:
To identify the anti-mutagenic effect of Nigella sativa
on the experimentally induced chronic diabetes (type – II) in
Wistar rats.
Materials and Methods: The anti-mutagenic effect was evaluated
in Nigella sativa treated diabetic rats against the
streptozotocin - nicotinamide (STZ-NA) (at a dose rate of 45-110
i.p mg/kg b.wt for 90 days) induced type-II diabetes mellitus
using bone marrow micronucleus tests. The antioxidant status was
tested by estimating the serum levels of lipid peroxidation and
superoxide dismutase.
Results: Our results indicated that diabetic rats treated with
Nigella sativa decreased the frequency of micronuclei in
the erythrocytes of bone marrow (P < 0.05) and enhanced the
antioxidant status (P < 0.05) in the treated diabetic rats
as compared to controls.
Conclusion: The observations indicated that the diabetic
patients are more prone to cell mutations which are related to the
level of cellular oxidative status and it could be reduced by
Nigella sativa.
Keywords: antioxidant, diabetes, micronucleus test,
Nigella sativa, plant extract
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