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Open Access
Copyright: The authors. This article is an open access
article licensed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/2.0) which permits unrestricted use,
distribution and reproduction in any medium, provided the work is properly
cited.
Research
(Published
online: 31-01-2014)
11. Study on antipyretic activity of
Rumex vesicarius leaves extract in albino rabbits -
Imran Ahmad Khan, Abdul Aziz, Zahid Manzoor, Shaukat Hussain
Munawar, Hafiz Shoaib Sarwar, Aqsa Afzal and Muhammad Asif Raza
Veterinary World, 7(1): 44-48
doi:
10.14202/vetworld.2014.44-48
Abstract
Aim: The present study was
planned to investigate the possible antipyretic activity of
methanolic leaves extract of Rumex vesicarius against various
protocols of experimentally induced pyrexia in rabbits.
Materials and Methods: Ninety healthy adult albino rabbits
were divided into three groups (A, B, C), 30 rabbits in each
group. Pyrexia was induced by three different protocols, i.e.
boiled milk (0.5 ml/kg body weight, intra-peritonealy), Brewer's
yeast (10 ml/kg, subcutenously) and D-amphetamine (5 mg/kg, i.p.),
to the groups A, B and C respectively. Each group was further
subdivided into five sub groups (1, 2, 3, 4 and 5) each having 6
animals. Sub group-1 served as positive control group; sub group-2
was treated with aspirin (10 mg/kg, orally) standard antipyretic
agent; sub group-3, 4 and 5 were treated orally with methanolic
leaves extract of Rumex vesicarius at dose rate of 80, 120 and 160
mg/kg body weight respectively. The hypothermic effect was
observed at different time intervals in each protocol.
Results: Rumex vesicarius L. significantly (p<0.05) lowered
the elevated temperature in all scenarios. Maximum antipyretic
effect was observed at 3h of post induction pyrexia in group A and
at 4h after pyrexia in the groups B and C. Moreover, the
antipyretic effect was concentration dependent and comparable to
the standard aspirin at higher doses.
Conclusion: The leaves of Rumex vesicarius have the
antipyretic action in dose dependent manner, based upon this
scientific validation, the claims of the local communities are
true. The exact mode of action of this plant is still not clear,
however, a single or a number of bioactive compounds of the plant
may be responsible for its antipyretic activity.
Keywords: aspirin, D-amphetamine, pyrexia, rabbits, Rumex
vesicarius (L.).
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