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Research
(Published
online: 05-10-2014)
3.
Antitrypanosomal effect of methanolic
extract of
Zingiber officinale (ginger) on
Trypanosoma brucei brucei-infected
Wistar mice -
P. I. Kobo, P. J.
Erin, M. M. Suleiman, H. Aliyu, M. Tauheed, S. Muftau and M.
Mamman
Veterinary World, 7(10): 770-775
doi:
10.14202/vetworld.2014.770-775
P. I.
Kobo:
Department of Veterinary Pharmacology and Toxicology, Faculty of
Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria;
patriciakobo@yahoo.com
P. J.
Erin:
Department of Veterinary Pharmacology and Toxicology, Faculty of
Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria;
pius4u2c@yahoo.com
M. M.
Suleiman:
Department of Veterinary Pharmacology and Toxicology, Faculty of
Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria;
mohsulai@yahoo.com
H.
Aliyu:
Department of Veterinary Pharmacology and Toxicology, Faculty of
Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria;
haliyu63@gmail.com
M.
Tauheed:
Department of Veterinary Pharmacology and Toxicology, Faculty of
Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria;
mtauheed40@yahoo.com
S.
Muftau:
Department of Veterinary Pharmacology and Toxicology, Faculty of
Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria;
shittumuftau@yahoo.com
M.
Mamman: Department of Veterinary Pharmacology and Toxicology,
Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria,
Nigeria;
mammanm@hotmail.com
Received:
15-05-2014, Revised: 18-08-2014, Accepted: 24-08-2014, Published
online: 05-10-2014
Corresponding author:
Patricia Ishaku Kobo, e-mail: patriciakobo@yahoo.com
Abstract
Aim:
The study was carried out to determine the in vivo
antitrypanosomal effect of methanolic extract of Zingiber
officinale (ginger) in Trypanosoma brucei brucei-infected
mice.
Materials and Methods: Twenty-five mice were randomly
allocated into five groups of five animals each. Group I and II
were given Tween 80 (1 ml/kg) and diminazene aceturate (3.5 mg/kg)
to serve as untreated and treated controls, respectively. Groups
III-V received the extract at 200, 400 and 800 mg/kg body weight,
respectively. All treatments were given for 6 consecutive days and
through the oral route. The mean body weight, mean survival period
and daily level of parasitaemia were evaluated.
Results: Acute toxicity showed the extract to be relatively
safe. There was an insignificant increase in body weight and
survival rate of mice treated with the extract. The level of
parasitaemia in the extract treated groups was decreased.
Conclusion: This study shows the in vivo potential of
methanolic extract of Z. officinale in the treatment of
trypanosomiasis.
Keywords: parasitaemia, survival rate, trypanosomiasis,
Zingiber officinale.
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