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R esearch
(Published online:
12-04-2015)
10.
Clinico-hemato-biochemical profile of dogs with liver cirrhosis
-
M. A.
Elhiblu, K. Dua, J. Mohindroo, S. K. Mahajan, N. K. Sood and P. S.
Dhaliwal
Veterinary World, 8(4): 487-491
doi:
10.14202/vetworld.2015.487-491
M. A. Elhiblu: Department of
Veterinary Medicine, Guru Angad Dev Veterinary and Animal Sciences
University, Ludhiana - 141 004, Punjab, India; muradelhiblu@yahoo.com
K. Dua: Department of Veterinary
Medicine, Guru Angad Dev Veterinary and Animal Sciences
University, Ludhiana - 141 004, Punjab, India; kirtidua@yahoo.com
J. Mohindroo: Department of
Veterinary Surgery and Radiology, Guru Angad Dev Veterinary and
Animal Sciences University, Ludhiana - 141 004, Punjab, India;
jmohindroo@yahoo.co.in
S. K. Mahajan: Department of
Veterinary Surgery and Radiology, Guru Angad Dev Veterinary and
Animal Sciences University, Ludhiana - 141 004, Punjab, India;
skmahajan73@yahoo.co.in
N. K. Sood :
Department of
Teaching Veterinary Clinical Complex, Guru Angad Dev Veterinary
and Animal Sciences University, Ludhiana - 141 004, Punjab, India;
nareshsood47@gmail.com
P. S. Dhaliwal: Department of
Veterinary Medicine, Guru Angad Dev Veterinary and Animal Sciences
University, Ludhiana - 141 004, Punjab, India; dhaliwalpps@yahoo.com
Received: 04-11-2014, Revised: 01-03-2015, Accepted: 09-03-2015,
Published online: 12-04-2015
Corresponding author:
K. Dua;
e-mail: kirtidua@yahoo.com
Citation:
Elhiblu MA, Dua K, Mohindroo J, Mahajan SK, Sood NK, Dhaliwal PS
(2015) Clinico-haemato-biochemical profile of dogs with liver
cirrhosis, Veterinary World 8(4): 487-491.
Abstract
Aim: The aim of this study
was to determine the relevant tools in the diagnosis of liver
cirrhosis in dogs.
Material and Methods: A total of 140 dogs presented at
Veterinary Teaching Hospital, Guru Angad Dev Veterinary and Animal
Sciences University, Ludhiana, showing clinical signs of hepatic
insufficiency were subjected to clinico-hemato biochemical,
urological, ultrasonographic (USG), and USG guided fine-needle
biopsy examinations by standard methods. On the basis of these
results, 6 dogs out of 140 dogs were found to be suffering from
liver cirrhosis. Six clinically healthy dogs constituted the
control group.
Results: The dogs suffering from liver cirrhosis manifested
inappetence, halitosis, abdominal distension, weight loss, melena,
icterus, anemia, and neutrophilic leukocytosis with the left
shift. Levels of hemoglobin, lymphocytes, packed cell volume, mean
corpuscular volume, mean corpuscular Hb (MCH), and platelet count
were significantly lower in liver cirrhosis group than control
group while total leukocyte count, neutrophils, and MCH
concentration were significantly higher. Glucose, total protein,
albumin, A/G ratio, and fibrinogen were significantly lower, and
creatinine, alanine aminotransferase, aspartate aminotransferase,
alkaline phosphatase, prothrombin time, and APTT were
significantly higher than the control values. Ultrasound revealed
diffuse increase in echogenicity with rounded and irregular liver
margins. Cytological examination of the ascitic fluid and
fine-needle aspiration biopsy of liver was not fruitful in the
diagnosis of liver cirrhosis.
Conclusions: Liver cirrhosis causes clinical and hemo-biochemical
alterations, which require special consideration when treating
diseased animals. USG, diffuse increase in echogenicity of liver,
rounding and irregularity of liver margins and microhepatica were
the consistent findings. It is suggested that USG along with hemo-biochemical
alterations may be used as a diagnostic tool for liver cirrhosis
in dogs.
Keywords: biochemistry, coagulation profile, dogs, hematology,
liver cirrhosis, ultrasonography.
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