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R esearch
(Published online:
19-04-2015)
14.
Pharmacokinetic interaction of curcumin and
glibenclamide in diabetic rats - P. R. Sakunthala Devi,
A. Gopala Reddy, G. S. Rao, C. S. V. Satish Kumar and G. Boobalan
Veterinary World, 8(4): 508-511
doi:
10.14202/vetworld.2015.508-511
P.
R. Sakunthala Devi:
Department of Veterinary Pharmacology and Toxicology, College of
Veterinary Science, Sri Venkateswara Veterinary
University, Tirupati - 517 502, Andhra Pradesh, India;
sakunthalavet@gmail.com
A.
Gopala Reddy:
Department of Veterinary Pharmacology and Toxicology, College of
Veterinary Science, Sri Venkateswara Veterinary
University, Tirupati - 517 502, Andhra Pradesh, India;
gopalareddy123@rediffmail.com
G.
S. Rao:
Department of Veterinary Pharmacology & Toxicology, NTR College of
Veterinary Science, Sri Venkateswara Veterinary University,
Tirupati - 517 502, Andhra Pradesh, India;
raogs64@rediffmail.com
C.
S. V. Satish Kumar:
Department of Veterinary Pharmacology and Toxicology, College of
Veterinary Science, Sri Venkateswara Veterinary
University, Tirupati - 517 502, Andhra Pradesh, India;
satish513512@gmail.com
G.
Boobalan: Department of Veterinary Pharmacology and
Toxicology, College of Veterinary Science, Sri Venkateswara
Veterinary
University, Tirupati - 517 502, Andhra Pradesh, India;
bhupalvets@gmail.com
Received: 30-11-2014, Revised: 13-03-2015, Accepted: 19-03-2015,
Published online: 19-04-2015
Corresponding author:
P. R. Sakunthala Devi, email: sakunthalavet@gmail.com
Citation:
Sakunthala Devi PR, Gopala Reddy A, Rao GS, Satish Kumar
CSV, Boobalan G (2015) Pharmacokinetic interaction of curcumin and
glibenclamide in diabetic rats, Veterinary World 8(4): 508-511.
Abstract
Aim:
The aim was to assess the pharmacokinetic (PK) interaction of
curcumin and glibenclamide (GL) in diabetic rats.
Materials and Methods: Sprague-Dawley rats induced with
diabetes were divided into 2 groups of six rats in each. Group I:
GL (6 mg/kg po once daily) treatment in diabetic rats and
group 2: Curcumin (50 mg/Kg po once daily) + GL (dose as
above) in diabetic rats. Blood samples were collected at
pre-determined time intervals for kinetic analysis after the first
and last oral dosing of GL for single and multiple dose studies,
respectively. Plasma samples were assayed for GL concentration by
high-performance liquid chromatography and PK parameters were
analyzed.
Results: The half-life (t 1/2) and mean
residence time (MRT) of GL were significantly increased in
curcumin pre-treated rats as compared to GL alone in single and
multiple dose studies. Similarly, the Vdss
was significantly increased in curcumin pre-treated
rats in single dose study as compared to GL alone treated group,
but no significant difference was observed in multiple dose
kinetics.
Conclusion: The study revealed higher values (t 1/2,
MRT and Vdss)
of GL in curcumin pre-treated group due to the inhibitory effect
of curcumin on intestinal CYP3A4.
Key words: curcumin, glibenclamide,
pharmacokinetics, CYP3A4
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