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Review
(Published
online: 13-01-2015)
10.
Heat shock
proteins: a therapeutic target worth to consider -
Amita Dubey, K. S. Prajapati,
Madhu Swamy and V. Pachauri
Veterinary World, 8(1): 46-51
doi:
10.14202/vetworld.2015.46-51
Amita
Dubey:
Department of Pathology, College of veterinary science & AH, NDVSU,
Jabalpur, Madhya Pradesh, India; amiabhishek@rediffmail.com
K. S.
Prajapati:
Department of Pathology, College of veterinary science & AH, AAU,
Anand, Gujarat, India; kanti_prajapati@yahoo.com
Madhu
Swamy:
Department of Pathology, College of veterinary science & AH, NDVSU,
Jabalpur, Madhya Pradesh, India; vetpath@rediffmail.com
V.
Pachauri:
Krishi Vigyan Kendra, Jawaharlal Nehru Agricultural University,
Sagar, Madhya Pradesh, India; dr.vivekinpachauri@gmail.com
Received: 08-09-2014, Revised: 20-11-2014, Accepted: 28-11-2014,
Published online: 13-01-2015
Corresponding author:
Amita Dubey, e-mail: amiabhishek@rediffmail.com
Abstract
Heat
shock proteins (HSPs) are the molecular chaperones, that are not
only expressed during the normal growth process of cell cycle
consecutively, but also get induced in cells during various stress
conditions produced by cellular insult, environmental changes,
temperature, infections, tumors etc. According to their molecular
weight and functions, HSPs are divided into five major families.
HSP90, HSP70, HSP60 and HSP100 are the most studied members of the
family. Experimental studies have proved that overexpression
and/or inhibition of HSPs play an important role in maintaining
the tolerance and cell viability under above-described stress
conditions. HSP90 is found to be a promising candidate for the
diagnosis, prognosis and treatment of cancer. Similarly, HSP70,
HSP60 and small HSPs experimentally and clinically have potential
for the treatment of neurodegenerative disease, ischemia, cell
death, autoimmunity, graft rejection, etc. In a way, exploring,
the cytoprotective and immunoregulatory role of HSPs can open a
new avenue for the drug discovery and treatment of critical
diseases.
Keywords: heat shock protein, heat shock
protein 70, heat shock protein 90, stress protein, small heat
shock proteins.
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