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R esearch
(Published online:
22-05-2015)
15.
Reproductive responses of dairy cows with ovarian cysts to
simultaneous human chorionic gonadotropin or gonadotropin-releasing
hormone and cloprostenol compared to gonadotropin-releasing
hormone alone treatment
-
T.
Taktaz, M. Kafi, Adel Mokhtari and M. Heidari
Veterinary World, 8(5): 640-644
doi:
10.14202/vetworld.2015.640-644
T. Taktaz: Department
of Animal Clinical Science, Shahrekord Branch, Islamic Azad
University, Shahrekord, Iran;
Taghi_taktaz@yahoo.com
M. Kafi: Department of
Animal Reproduction, Faculty of Veterinary Medicine, Shiraz
University, Shiraz, Iran;
Kafi@shirazu.ac.ir
Adel Mokhtari:
Department of
Animal Reproduction, Faculty of Veterinary Medicine, Shiraz
University, Shiraz, Iran;
adelmkh2008@yahoo.com
M. Heidari: Department
of Animal Clinical Science, Shahrekord Branch, Islamic Azad
University, Shahrekord, Iran;
milad391@yahoo.com
Received:
18-11-2014,
Revised:
13-04-2015, Accepted:
21-04-2015, Published
online:
22-05-2015
Corresponding author:
Adel Mokhtari, e-mail: adelmkh2008@yahoo.com
Citation:
Taktaz
T, Kafi M, Mokhtari A, Heidari M (2015) Reproductive responses of
dairy cows with ovarian cysts to simultaneous human chorionic
gonadotropin or gonadotropin releasing hormone and cloprostenol
compared to gonadotropin releasing hormone alone treatment,
Veterinary World 8(5):640-644.
Abstract
Aim: Bovine ovarian cysts
are a common cause of economic loss in modern dairy herds. The
objective of the present study was to evaluate the reproductive
responses to three protocols using hCG, GnRH and cloprostenol when
the definite diagnosis of the type of ovarian cyst is/is not
possible in dairy cows.
Materials and Methods: A total of 144 lactating dairy cows
with ovarian cysts were divided into three groups. At diagnosis
(Day 0), cows in Group 1 (the conventional method, n=47) were
injected with 0.02 mg of a GnRH analogue i.m. (Buserelin); cows in
Group 2 (n=47) were intramuscularly treated with 0.02 mg Buserelin
plus 500 μg cloprostenol; and cows in Group 3 (n=50) were
intramuscularly treated with 1500 IU hCG plus 500 μg cloprostenol.
All cows received 500 μg cloprostenol intramuscularly on Day 10.
Results: No statistically significant differences were found
in the recovery time, interval to conception, conception rate at
first AI, and pregnancy rates by Days 70 and 100 after treatment
among the three groups.
Conclusions: Simultaneous treatment of ovarian cysts with hCG
or GnRH and cloprostenol appeared to have no advantage over the
conventional method, GnRH alone, in dairy cows. Furthermore, hCG
and GnRH have an equal therapeutic effect in cows with ovarian
cysts.
Keywords: cloprostenol, dairy cows, GnRH, hCG, ovarian cyst.
References
1. Vanholder, T., Opsomer, G. and de Kruif, A. (2006)
Aetiology and pathogenesis of cystic ovarian follicles in
dairy cattle: A review. Reprod. Nutr. Dev., 46(2): 105-119.
http://dx.doi.org/10.1051/rnd:2006003
PMid:16597418 |
|
|
2. Garverick, H.A. (1997) Ovarian follicular cysts in dairy
cows. J. Dairy Sci., 80(5): 995-1004.
http://dx.doi.org/10.3168/jds.S0022-0302(97)76025-9 |
|
|
3. Fourichon, C., Seegers, H. and Malher, X. (2000) Effect of
disease on reproduction in the dairy cow: A meta-analysis.
Theriogenology, 53(9): 1729-1759.
http://dx.doi.org/10.1016/S0093-691X(00)00311-3 |
|
|
4. Lopez-Diaz, M.C. and Bosu, W.T.K. (1992) A review and an
update of cystic ovarian degeneration in ruminants.
Theriogenology, 37(6): 1163-1183.
http://dx.doi.org/10.1016/0093-691X(92)90173-O |
|
|
5. Borsberry, S. and Dobson, H. (1989) Periparturient diseases
and their effect on reproductive performance in five dairy
herds. Vet. Rec., 124(9): 217-219.
http://dx.doi.org/10.1136/vr.124.9.217 |
|
|
6. Hooijer, G.A., Lubbers, R.B., Ducro, B.J., van Arendonk,
J.A., Kaal-Lansbergen, L.M. and van der Lende, T. (2001)
Genetic parameters for cystic ovarian disease in dutch black
and white dairy cattle. J. Dairy Sci., 84(1): 286-291.
http://dx.doi.org/10.3168/jds.S0022-0302(01)74478-5 |
|
|
7. Probo, M., Comin, A., Mollo, A., Cairoli, F., Stradaioli,
G. and Veronesi, M.C. (2011) Reproductive performance of dairy
cows with luteal or follicular ovarian cysts after treatment
with buserelin. Anim. Reprod. Sci., 127(3-4): 135-139.
http://dx.doi.org/10.1016/j.anireprosci.2011.07.019
PMid:21920681 |
|
|
8. Cattaneo, L., Signorini, M., Bertoli, J., Bartolomé, J.,
Gareis, N., Díaz, P., Bó, G. and Ortega, H. (2014)
Epidemiological description of cystic ovarian disease in
argentine dairy herds: Risk factors and effects on the
reproductive performance of lactating cows. Reprod. Domest.
Anim., 49(6): 1028-1033.
http://dx.doi.org/10.1111/rda.12432
PMid:25292292 |
|
|
9. Amweg, A.N., Salvetti, N.R., Stangaferro, M.L., Paredes,
A.H., Lara, H.H., Rodríguez, F.M. and Ortega, H.H. (2013)
Ovarian localization of 11β-hydroxysteroid dehydrogenase
(11βHSD): effects of ACTH stimulation and its relationship
with bovine cystic ovarian disease. Domest. Anim. Endocrinol.,
45(3): 126-140.
http://dx.doi.org/10.1016/j.domaniend.2013.07.001
PMid:23972491 |
|
|
|
10. Kahn, C.M. (2010) Cystic ovary disease. In: Line, S.,
editor. The Merck Veterinary Manual. 10th ed. Merck,
Whitehouse Station, NJ. p1243-1247. |
|
|
11. Amiridis, G.S. (2009) Comparison of aspiration and
hormonal therapy for the treatment of ovarian cysts in cows.
Acta Vet. Hung., 57(4): 521-529.
http://dx.doi.org/10.1556/AVet.57.2009.4.6
PMid:19897456 |
|
|
12. Roth, Z., Biran, D., Lavon, Y., Dafni, I., Yakobi, S. and
Braw-Tal, R. (2012) Endocrine milieu and developmental
dynamics of ovarian cysts and persistent follicles in
postpartum dairy cows. J. Dairy Sci., 95(4): 1729-1737.
http://dx.doi.org/10.3168/jds.2011-4513
PMid:22459821 |
|
|
13. Gundling, N., Drews, S. and Hoedemaker, M. (2009)
Comparison of two different programmes of ovulation
synchronization in the treatment of ovarian cysts in dairy
cows. Reprod. Domest. Anim., DOI:
10.1111/j.1439-0531.2009.01342.x.
http://dx.doi.org/10.1111/j.1439-0531.2009.01342.x |
|
|
14. Rizzo, A., Campanile, D., Mutinati, M., Minoia, G.,
Spedicato, M. and Sciorsci, R.L. (2011) Epidural vs
intramuscular administration of lecirelin, a GnRH analogue,
for the resolution of follicular cysts in dairy cows. Anim.
Reprod. Sci., 126(1-2): 19-22.
http://dx.doi.org/10.1016/j.anireprosci.2011.04.013
PMid:21571459 |
|
|
15. Kawate, N., Watanabe, K., Uenaka, K., Takahashi, M.,
Inaba, T. and Tamada, H. (2011) Comparison of plasma
concentrations of estradiol-17β and progesterone, and
conception in dairy cows with cystic ovarian diseases between
Ovsynch and Ovsynch plus CIDR timed AI protocols. J. Reprod.
Dev., 57(2): 267-272.
http://dx.doi.org/10.1262/jrd.10-066T |
|
|
16. Sprecher, D.J., Strelow, L.W. and Nebel, R.L. (1990) The
response of cows with cystic ovarian degeneration to
luteotropic or luteolytic therapy as assigned by latex
agglutination milk progesterone assay. Theriogenology, 34:
1149-1158.
http://dx.doi.org/10.1016/S0093-691X(05)80014-7 |
|
|
17. el-Tahawy, Ael-G. and Fahmy, M.M. (2011) Partial budgeting
assessment of the treatment of pyometra, follicular cysts and
ovarian inactivity causing postpartum anoestrus in dairy
cattle. Res. Vet. Sci., 90(1): 44-50.
http://dx.doi.org/10.1016/j.rvsc.2010.04.017
PMid:20466393 |
|
|
18. Rizzo, A., Spedicato, M., Mutinati, M., Minoia, G.,
Pantaleo, M. and Sciorsci, R.L. (2011) In vivo and in vitro
studies of the role of the adrenergic system and follicular
wall contractility in the pathogenesis and resolution of
bovine follicular cysts. Theriogenology, 76(8): 1526-1531.
http://dx.doi.org/10.1016/j.theriogenology.2011.06.024
PMid:21803406 |
|
|
19. Nakao, T., Tomita, M., Kanbayashi, H., Takagi, H., Abe,
T., Takeuchi, Y., Ochiai, H., Moriyoshi, M. and Kawata, K.
(1992) Comparisons of several dosages of a GnRH analog with
the standard dose of hCG in the treatment of follicular cysts
in dairy cows. Theriogenology, 38(1): 137-145.
http://dx.doi.org/10.1016/0093-691X(92)90225-G |
|
|
20. De Rensis, F., López-Gatius, F., García-Ispierto, I. and
Techakumpu, M. (2010) Clinical use of human chorionic
gonadotropin in dairy cows: an update. Theriogenology, 73(8):
1001-1008.
http://dx.doi.org/10.1016/j.theriogenology.2009.11.027
PMid:20116839 |
|
|
21. Leslie, K.E. and Bosu, W.T. (1983) Plasma progesterone
concentrations in dairy cows with cystic ovaries and clinical
responses following treatment with fenprostalene. Can. Vet.
J., 24(11): 352-356.
PMid:17422330 PMCid:PMC1790459 |
|
|
22. Chavatte, P.M., Archbald, L.F., Risco, C., Tran, T. and
Sumrall, D. (1993) Effectiveness of prostaglandin F2alpha in
the initial treatment of bovine ovarian cysts. Theriogenology,
40(4): 745-755.
http://dx.doi.org/10.1016/0093-691X(93)90210-V |
|
|
23. Douthwaite, R. and Dobson, H. (2000) Comparison of
different methods of diagnosis of cystic ovarian disease in
cattle and an assessment of its treatment with a
progesterone-releasing intravaginal device. Vet. Rec.,
147(13): 355-359.
http://dx.doi.org/10.1136/vr.147.13.355 |
|
|
24. Farin, P.W., Youngquist, R.S., Parfet, J.R. and Garverick,
H.A. (1992) Diagnosis of luteal and follicular ovarian cysts
by palpation per rectum and linear-array ultrasonography in
dairy cows. J. Am. Vet. Med. Assoc., 200(8): 1085-1089.
PMid:1607312 |
|
|
25. White, M.E. and Reimers, T.J. (1986) Milk progesterone
concentrations following simultaneous administration of
buserelin and cloprostenol in cattle with normal corpora
lutea. Can. J Vet Res., 50(2): 285-286.
PMid:3093040 PMCid:PMC1255206 |
|
|
26. Dinsmore, R.P., White, M.E. and English, P.B. (1990) An
evaluation of simultaneous GnRH and cloprostenol treatment of
dairy cattle with cystic ovaries. Can. Vet. J., 31(4):
280-284.
PMid:17423558 PMCid:PMC1480688 |
|
|
27. López-Gatius, F. and López-Béjar, M. (2002) Reproductive
performance of dairy cows with ovarian cysts after different
GnRH and cloprostenol treatments. Theriogenology, 58(7):
1337-1348.
http://dx.doi.org/10.1016/S0093-691X(02)00952-4 |
|
|
28. Morrow, D.A., Roberts, S.J. and McEntee, K. (1969)
Postpartum ovarian activity and involution of the uterus and
cervix in dairy cattle. 1. Ovarian activity. Cornell. Vet.,
59(2): 173-190.
PMid:5813740 |
|
|
29. Dinsmore, R.P., White, M.E., Guard, C.L., Jasko, D.J.,
Perdrizet, J.A., Powers, P.M. and Smith, M.C. (1989) Effect of
gonadotropin-releasing hormone on clinical response and
fertility in cows with cystic ovaries, as related to milk
progesterone concentration and days after parturition. J. Am.
Vet. Med. Assoc., 195(3): 327-330.
PMid:2670861 |
|
|
30. Koppinen, J., Vesanen, M. and Alanko, M. (1984) Ovarian
cysts in dairy cattle-some aspects of diagnosis, treatment
with GnRH and HCG and subsequent milk progesterone values.
Nord. Vet. Med., 36(1-2): 26-31.
PMid:6374616 |
|
|
31. Kesler, D.J., Garverick, H.A., Caudle, A.B., Bierschwal,
C.J., Elmore, R.G. and Youngquist, R.S. (1978) Clinical and
endocrine response of dairy cows with ovarian cysts to GnRH
and PGF2α. J. Anim. Sci., 46: 719-725.
PMid:350819 |
|
